FATP是脂肪酸转运蛋白（fatty acid transport proteins），主要用于运输长链脂肪酸，至少有六种（FATP1-6），各有不同的专一性和组织分布。 脂肪酸与转运蛋白结合后，表观pKa从水溶液中的4.5升高到7.6，结果大约一半的脂肪酸不带电荷，从而能够穿过磷脂双层。 在质膜的内表面，脂肪酸可以与胞质脂肪酸结合蛋白（FABPc）或小窝蛋白1（Caveolin-1）结合。 FABPc使脂肪酸保持可溶性，并可以在细胞内运输到各个细胞区室（细胞器）。 脂肪酸氧化前要先活化，即生成 …

2020年9月21日 · Restricting CD36 at either palmitoylated or depalmitoylated state eliminates its FA uptake activity, indicating an essential role of dynamic palmitoylation of CD36. Furthermore, blocking...

2012年6月28日 · 目前已发现协助长链脂肪酸转运的载体膜蛋白主要包括脂肪酸转运蛋白家族 帆 能 等 等 、脂肪酸转位酶 哆 等 和膜脂肪酸结合蛋白 等 。

Several proteins have been implicated in fatty acid (FA) transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1) a member of the CD36 family and the FA transport protein 4 (FATP4). Here, we review ...

2021年9月24日 · CD36 expression results in metabolic reprogramming, with a shift towards fatty acid oxidation. CD36 inhibition induces de novo lipogenesis in breast cancer cells. Increased CD36 expression...

1999年10月18日 · In this review we discuss three candidate proteins: FABPm, FAT/CD36 and FATP which have been cloned and are currently being characterized. Recent evidence arguing for an important role of the fatty acid transport step in general metabolism and linking these proteins to physiologic or metabolic abnormalities is described.

1999年10月18日 · Identification of the mammalian membrane fatty acid transporter(s) has been the focus of active investigation by several research groups. In this review we discuss three candidate proteins: FABPm, FAT/CD36 and FATP which have been cloned and are currently being characterized.

CD36 is a scavenger receptor that functions in high affinity tissue uptake of long chain fatty acids (FA) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer.

2016年10月1日 · In this review we discuss our current knowledge about the role of CD36 in cardiac fatty acid uptake and metabolism in health and disease with focus on the regulation of the subcellular trafficking of CD36 and its selective modulation as …

哺乳动物膜脂肪酸转运蛋白的鉴定一直是几个研究小组积极研究的重点。在这篇综述中，我们讨论了三种候选蛋白：fabpm，fat / cd36和fatp，它们已经被克隆并且正在被表征。