CD38-Mediated Immunosuppression as a Mechanism of Tumor …
Significance: CD38 is a major mechanism of acquired resistance to PD-1/PD-L1 blockade, causing CD8 + T-cell suppression. Coinhibition of CD38 and PD-L1 improves antitumor …
Dysregulated CD38 Expression on Peripheral Blood Immune Cell …
Given its uniformly high expression on plasma cells, CD38 has been considered as a therapeutic target in patients with systemic lupus erythematosus (SLE). Herein, we investigate the …
CD38 deletion to preserve CAR T cell metabolism and promote …
2024年9月19日 · The deletion of CD38 confers the relative resistance of CAR T cells to exhaustion in vitro and improved tumor control in vivo. After the deletion of either CD38 or …
A Regulatory Feedback between Plasmacytoid Dendritic Cells and ...
2016年3月15日 · Here we report an "auto"-regulatory feedback mechanism between plasmacytoid dendritic cells (pDCs) and Breg cells. In healthy individuals, pDCs drive the differentiation of …
CD38–RyR2 axis–mediated signaling impedes CD8 - PNAS
2024年3月7日 · Exploring the underlying molecular mechanism reveals the crucial role of the CD38-induced signaling cascade in contributing to the development of immunotherapy …
Regulation of CD38 on Multiple Myeloma and NK Cells by …
The CD38 + plasmacytoid dendritic cells (pDCs) confer a growth and survival advantage to MM cells by decreasing the pDC antitumor function 86. Daratumumab induces progressive …
CD38 as a novel immune checkpoint and a mechanism of …
2017年3月1日 · To test whether CD38 blockade might be therapeutically efficacious to anti-PD-L1 resistance, we applied the combination therapy of anti-CD38 and anti-PD-L1 and …
CD38: An important regulator of T cell function - PubMed
In this paper, we reviewed the role and mechanism of CD38 + CD4 + T cells / CD38 + CD8 + T cells in cellular immunity and the effects of the CD38-NAD + axis on T cell activity. We also …
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1 - Nature
2019年7月29日 · We show that PD-1 blockade in suboptimally primed CD8 + T cell conditions results in the generation of dysfunctional PD-1 + CD38 hi CD8 + cells 18, leading to resistance …
CD38 symmetric dimethyl site R58 promotes malignant tumor cell …
2024年10月15日 · Here, we demonstrate that CD38 is highly expressed in malignant tumors (lung cancer, nasopharyngeal carcinoma, cervical cancer) and upregulates PD-L1 protein …
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