Hepatitis B virus-specific CD4 T cell responses differentiate ...
Results: ELISpot screening readily identified HBV-specific CD4 and CD8 T cell responses in acute resolving infection compared with more limited reactivity in chronic infection. Applying more …
CD4+ T Cells in Chronic Hepatitis B and T Cell-Directed …
In this review, we summarize what is known about CD4 + T cells in chronic HBV infection and discuss the importance and opportunities of including CD4 + T cells in T cell-directed …
TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with ...
TNF-α producing cells are the dominant population of hepatitis B virus (HBV)-specific CD4 T cells in patients with chronic HBV infection. This population of cells might contribute to the …
专家论坛｜邓国宏：慢性HBV感染者病毒特异性T淋巴细胞：耗竭 …
Jun 23, 2020 · 体外刺激hbv特异性cd4 t淋巴细胞上ox40分子（抗原递呈细胞上共刺激分子ox40l的配体）、同时阻断pd-1分子，能显著提升hbv特异性 ifnγ+及il-21+ cd4 t淋巴细胞的数量，这提 …
Differential response of HBV envelope-specific CD4
Mar 13, 2023 · In this study, using a series of samples from a longitudinal cohort of CHB patients with NA discontinuation and peptides spanning the whole HBV genome, we found boosted …
CD4 + T Cells in Chronic Hepatitis B and T Cell-Directed
May 6, 2021 · In this review, we summarize what is known about CD4 + T cells in chronic HBV infection and discuss the importance and opportunities of including CD4 + T cells in T cell …
HBV特异性CD4 T细胞的TNF-α/IFN-γ表达谱与肝损伤和病毒清除 …
从产生hbv特异性tnf-α的cd4 t细胞分化为产生hbv特异性ifn-γ的cd4 t细胞可能有利于hbv病毒的清除。 在本研究中，作者首先分析了68例 丙氨酸氨基转移酶 （ALT）低于正常上限（ULN）2倍 …
J hepatology： HBV特异性CD4 T细胞的TNF-α/IFN-γ谱与慢性HBV …
Dec 31, 2019 · 在ALT <2xULN的患者中，在病毒清除水平升高的患者中，产生HBV特异性IFN-γ的CD4 T细胞的频率和优势依次增加：HBV e抗原（HBeAg）阳性，HBeAg阴性和HBV表面抗 …
CD40 stimulation activates CD8+ T cells and controls HBV in CD4 ...
Sep 1, 2024 · CD40 stimulation in CD4-depleted AAV-HBV mice resulted in the clearance of HBsAg and HBeAg, along with a reduction in liver HBV mRNA, contrasting with CD4 …
Hepatitis B virus-specific CD4 T cell responses differentiate ...
Our data indicate that higher frequencies of functional HBV-specific CD4 T cell responses are a key component of the immune signature associated with functional cure, and that direct ex …
- Some results have been removed