2024年2月21日 · Activated CD4 + T cells produce IFNβ via the STING pathway, which promotes MHC-I antigen (cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer responses. In...

In this study, utilizing a novel tractable IFN-γ and IL-10 dual reporter system, we have shown that IL-10–producing Ag-experienced CD4 + T cells generated during the early phases of primary malaria infection have limited ability to populate the memory CD4 + T cell compartment that functions during subsequent parasite infections.

2022年4月25日 · Here, we report that IFN-γ + CD4 + T cells display direct ex vivo cytolytic activity and demonstrate that genetic ablation of IFN-γ or its blockade inhibits CD4 + CTL generation in vivo. Results

Gamma interferon (IFN-gamma) is a key cytokine in host defense against intracellular mycobacterial infection. It has been believed that both CD4 and CD8 T cells are the primary sources of IFN-gamma. However, the relative contributions of CD4 and CD8 T-cell subsets to IFN-gamma production and the rel …

Activated CD4 + T cells produce IFNβ via the STING pathway, which promotes MHC-I antigen (cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer responses. In cooperation with CD40 ligand (L), IFNβ also optimizes the costimulatory and other functions of cDC1s required for CTL response induction.

Responsive tumors have an inflammatory and highly immune infiltrated pre-treatment tumor microenvironment characterized by the enrichment of pathways associated with CD4+T cells, interferons (IFNs), and tumor necrosis factor alpha (TNF-a).

2007年3月4日 · We observed significant increases of CD4 + T cells in the spleens of Ifngr −/− mice after treatment, demonstrating that the host's ability to respond to IFN-γ is necessary for the apoptosis ...

CD4 T cells are a significant source of IFN-γ during acute infection in mice and are required for control of bacterial growth and host survival. However, several other types of cells can and do produce IFN-γ during the course of the infection.

T cell production of the cytokine interferon (IFN)-γ plays a key role in both tumor control and graft-mediated pathology following hematopoietic transplantation. 1 CD4 + T cells become T H1 cells, a major IFN-γ-producing effector population, through the integration of activation-induced metabolic and epigenetic changes during their ...

2022年12月27日 · They find that a CD4 T cell associated inflammatory IFN/TNF-α gene signature is associated with response in a murine mesothelioma model and patients with breast cancer. Furthermore, chemotherapy efficacy can be improved by pre-treating tumors with targeted immunotherapy.