We have investigated the role of IP-10 in the establishment of HIV reservoirs in CD4 + T cells, and found that in HIV-infected individuals, plasma IP-10 was elevated, and positively …

cd4+t细胞作为免疫系统的关键组成部分，在协调适应性免疫反应中发挥着核心作用。 目前已鉴定出五种主要的CD4+T辅助细胞(Th)亚群： Th1、Th2、Th17、Treg（调节性T）和Tfh（滤泡辅 …

2008年12月15日 · IP(3) (inositol 1,4,5-trisphosphate) receptors (IP(3)Rs) regulate the release of Ca(2+) from intracellular stores in response to IP(3). Little is known about regulation of the …

2022年4月18日 · In HIV+ patients, blood IP-10 levels are increased and CXCR3 is up-regulated on memory CD4+ T cells [15,16,17]. In particular, the exposure of resting CD4+ T cells to …

CD4 + T cells orchestrate the CD8 + T cell and humoral responses after vaccination. Coordinating immune responses – humoral and cellular – is vital for protection against severe Covid-19. Our …

Whilst our study focused on IP-10 and sCD14 because of their link to HIV status and markers of disease progression described in literature, some studies have profiled between 15 and 28 …

2022年4月18日 · Several markers, such as the chemokine receptor CXCR3 and its pro-inflammatory ligand IP-10, have been proposed to define the size of HIV reservoirs in the …

2003年8月1日 · Here, we show that incubation of CD4 + Th cells with CD4-IP mobilized Ca 2+ and inhibited forskolin- and TCR-induced increases in intracellular cAMP concentrations …

2021年6月14日 · cd4 + t细胞是调节适应性免疫的重要细胞。 长期以来认为CD4 + T细胞有两个基本功能：促进炎症反应和促进B细胞产生抗体。 在20世纪80年代后期，Mossman …

IP delivery of AAV8-CBA-hF.IX in BALB/c neonates achieves stable, high level expression of hF.IX without induction of humoral response. Strain-specific differences in the immune …