Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen -presenting molecule that binds self and foreign lipids and glycolipids.

Natural killer T (NKT) cells are a developmentally and functionally distinct lineage of T cells restricted by CD1d–lipid antigen complexes. These cells branch from conventional...

2020年6月24日 · Key subsets of unconventional T cells include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells and γδ T cells; collectively, these make up ~10% of circulating T cells,...

Human iNKT cells can be CD4 +, CD8 + double-negative (CD4 − CD8 −), whereas NKT cells in mice are either CD4 + or CD4 − CD8 − [23,24,25]. This is due to mouse iNKT cells expressing the transcription factor Th-POK, which is necessary for proper iNKT development, but silences CD8 expression [ 26 ].

2003年8月1日 · CD1d-restricted NKT cells include CD4 + and CD4 − CD8 − double-negative (DN) subsets and express a heavily biased TCR repertoire, with the majority expressing an invariant Vα14Jα281 TCR-α-chain and Vβ8.2, Vβ2, or Vβ7 TCR-β-chains in mice.

Our findings provide new insights into the early development of NKT cells prior to surface expression of the invariant Valpha14 antigen receptor and suggest the possible alternative developmental pathway of NKT cells.

Although natural killer T cells (NKT cells) are thought to be generated from CD4+CD8+ (DP) thymocytes, the developmental origin of CD4−CD8− (DN) NKT cells has remained unclear. In this study, we found the level of NK1.1 expression was highest in DN ...

2010年2月7日 · The human CD4 + NKT subset produces both T helper type 1 (T H 1) and T H 2 cytokines, whereas CD4 − NKT cells produce mainly T H 1 cytokines 67,68.

Of relevance, NKT cells do indeed include a subset of CD4-NK1.1-IL-17-producing cells (Coquet et al., 2008). Moreover, NKT cells have been implicated in SLE pathogenesis where the activation of NKT cells through the administration of α-GalCer exacerbated disease whereas the inhibition of NKT cell activation using an anti-CD1d blocking antibody ...

2007年7月1日 · Using blocking reagents neutralizing CD4 binding, experimental systems where MHC class II molecules are absent and recombinant alpha-GalCer/CD1d complexes, we show that CD4 potentiates human iNKT cell activation by engaging CD1d molecules.