CD4 + T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4 + T cells are activated after interaction with antigen-MHC complex and differentiate into …

2015年4月16日 · Here, we describe a basic protocol for the isolation of naïve T cells from mouse and the subsequent steps necessary for polarizing naïve cells to various T helper effector …

In this mini review, we provide an overview of the mechanisms underlying human naïve CD4 + T-cell homeostasis, combining clinical data, experimental studies, and modeling approaches.

Naïve CD4+ T cells are one of many types of T lymphocytes in the human body. These cells are fully mature, but they have not been activated through an encounter with their target antigen. …

2023年5月8日 · Naive CD4 + T cells quiescently recirculate through blood (dark red) and lymphoid (light green) tissues. Upon infection, for example by a respiratory pathogen, APCs …

2024年11月21日 · In naive uninfected and unimmunized mice, we identified higher expression of programmed cell death protein 1 (PD-1) and CD73 mRNA and protein on self-specific CD4 + T …

2024年1月3日 · Here, we evaluated CD4 + T cell subpopulations using decomposition-based transcriptome characterization and canonical clustering strategies. This approach identified 12 …

2025年2月25日 · In this study, we identify distinct subpopulations within both murine and human naïve CD4 T cells by single cell-RNA-sequencing (scRNA-seq), particularly focusing on a …

CD4⁺T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4⁺T cells are activated after interaction with antigen-MHC complex and differentiate into …

We utilized multiple high-throughput technologies to derive a comprehensive profile of two primary human cell types, naïve CD4+ T cells and memory CD4+ T cells, from a single donor.