通常只有CD8+T细胞被认为具有消灭肿瘤的作用，但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。 本文回顾癌症背景下，细胞毒性CD4+T细胞的发育、作用和特征。 强调通过研究细胞毒性CD4+T细胞的作用，发展 免疫疗法。 细胞毒性CD4+T细胞在多类癌症中具有直接破坏肿瘤的作用。 细胞毒性CD4+T细胞可以为患者提供临床益处。 通过研究细胞毒性CD4+T细胞，可能会发展出更多创新和有效的免疫疗法。 CD4+T细胞通常在免疫系统中被认为起辅助作用，但研究已 …

TNF-α即 肿瘤坏死因子α ，也被称作 cachectin 和 TNFSF1A ，是TNF超家族的配体。它是一种多效细胞分子，在炎症、细胞凋亡和免疫系统发育中起着核心作用。

2023年6月14日 · CD4+ T-cell-derived IFNγ sensitises IFN-responsive melanoma cells for TNF-induced cell death. Myeloid cell-derived nitric oxide (NO) contributes to inflammatory cell death of IFN-unresponsive...

2022年12月27日 · Responsive tumors have an inflammatory and highly immune infiltrated pre-treatment tumor microenvironment characterized by the enrichment of pathways associated with CD4 + T cells, interferons (IFNs), and tumor necrosis factor alpha (TNF-α). The same gene expression profile is associated with response to cyclophosphamide-based chemotherapy in ...

CD4+ T细胞：CD4+ T细胞通过分化为不同的亚群（如Th1、Th2、Th17和Treg）来调节免疫应答。 Th1细胞主要产生干扰素γ（IFN-γ），促进细胞介导的免疫反应，包括增强CTL对肿瘤细胞的杀伤。

2023年5月8日 · Tumor-infiltrating CD4 + T cells kill cancer cells, destroy tumor vessels and sustain leukocyte responses mainly through the secretion of IFNγ, TNF and IL-2 (ref. 174). While most CD4 + T...

2022年11月16日 · TNFa is a pleiotropic cytokine that has both proinflammatory and regulatory effects on CD4 + T cells and can influence the adaptive immune response against autoantigens. Here, we critically appraise the literature and discuss the intricacies of TNFa signaling that may explain the controversial findings of previous studies.

2014年2月4日 · Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+...

2022年11月15日 · TNFa is a pleiotropic cytokine that has both proinflammatory and regulatory effects on CD4 + T cells and can influence the adaptive immune response against autoantigens. Here, we critically appraise the literature and discuss the intricacies of TNFa signaling that may explain the controversial findings of previous studies.

2022年12月27日 · Responsive tumors have an inflammatory and highly immune infiltrated pre-treatment tumor microenvironment characterized by the enrichment of pathways associated with CD4 + T cells, interferons (IFNs), and tumor necrosis factor alpha (TNF-α). The same gene expression profile is associated with response to cyclophosphamide-based chemotherapy in ...