ERK1/2 regulation of CD44 modulates oral cancer aggressiveness
2012年1月1日 · Aggressively growing cell lines displayed ERK1/2 activation, which stimulated expression of CD44, a marker associated with epithelial to mesenchymal transition and …
CD44 Promotes Lung Cancer Cell Metastasis through ERK …
2021年8月12日 · CD44 overexpression significantly increased migration and invasion abilities of lung cancer cells through CD44-induced ERK phosphorylation, ZEB1 upregulation, and …
CD44 signaling via PI3K/AKT and MAPK/ERK pathways protects …
We show that CD44 engagement protects CLL cells from spontaneous and fludarabine-induced apoptosis through activation of the PI3K/AKT and MAPK/ERK pathways resulting in increased …
Adhesion glycoprotein CD44 functions as an upstream regulator …
In this study, we describe a novel crosstalk among ERK, AKT and Hippo-YAP pathways, with CD44 as an upstream regulator. High cell density leads to activation of ERK and AKT but …
CD44 Signaling Via PI3K/AKT and MAPK/ERK Pathways Protects …
2008年11月16日 · To explore a possible role of this adhesion receptor in CLL, we evaluated the effect of CD44 engagement on the survival of CLL cells and the induction of drug resistance. …
CD44 regulates cell proliferation, migration, and invasion via ...
2015年9月1日 · CD44 was recently identified as a cancer initiation marker on the cell membrane. The cytoplasmic tail of CD44 is known to bind ERM (ezrin, radixin, moesin) proteins, …
Activated ERK1/2 increases CD44 in glomerular parietal epithelial …
Because our results showed de novo co-staining for activated ERK1/2 (pERK) in parietal epithelial cells in experimental FSGS, and also in biopsies from patients with FSGS, two in vitro …
CD44 Promotes Lung Cancer Cell Metastasis through ERK–ZEB1 …
CD44 overexpression significantly increased migration and invasion abilities of lung cancer cells through CD44-induced ERK phosphorylation, ZEB1 upregulation, and Claudin-1 …
CD44 信号通过 PI3K/AKT 和 MAPK/ERK 通路保护 CLL 细胞 ... - X …
CD44 的二聚化激活了 PI3K/AKT 和 MAPK/ERK 通路并导致 MCL-1 水平增加。 CD44 刺激的细胞中 MCL mRNA 没有增加，与对蛋白质稳定性的影响一致。 与这些抗凋亡机制的诱导一 …
CD44 potentiates hepatocellular carcinoma migration and …
Our in-vitro and in-vivo experiments showed that CD44 downregulation reduced HCC cell colony formation, migration, and invasion, and HCC tumor growth and metastasis, and that the pro …