CD45R (also known as CD45RABC) contains all three possible exons. It is the longest protein and migrates at 200 kDa when isolated from T cells. B cells also express CD45R with heavier glycosylation, bringing the molecular weight to 220 kDa, hence the name B220 (B cell isoform of 220 kDa). PTPRC has been shown to interact with: SKAP1. [18]

CD45R specifically has been shown to be essential in B cell receptor and T cell receptor signaling. It is primarily found on all developmental B cells including: Pro-B cell, Pre-B cell and up to mature B cells but is also found on T cell & NK cell subsets.

2024年3月1日 · CD45——蛋白酪氨酸磷酸酶受体C (PTPRC)，又被称为白细胞共同抗原（LCA)，是一种1型跨膜蛋白酪氨酸磷酸酶 (PTPase)，在除成熟红细胞和血小板外的所有造血干细胞谱系细胞中均有表达，是T和B细胞抗原受体介导的活化的重要调节因子。 CD45由两个胞内磷酸酶结构域、一个跨膜结构域和一个胞外结构域组成的大糖蛋白，分子量为180-220 kDa，约占阳性表达细胞表面抗原的10%。 蛋白酪氨酸激酶和磷酸酶活性之间的平衡失调 (来自CD45和其他) …

1998年1月30日 · Cells expressing only one of the three predominant types (CD45RO, CD45RC, and CD45RAC) or the minor species (CD45RA) of porcine CD45 on their surface were sorted based on positive reactivity with the CD45 mAb K252.1E4.

Invitrogen Anti-CD45R (B220) Monoclonal (RA3-6B2), eBioscience™, Catalog # 14-0452-82. Tested in Immunohistochemistry (Frozen) (IHC (F)), Immunohistochemistry (Paraffin) (IHC (P)), Flow Cytometry (Flow) and Immunoprecipitation (IP) applications. This antibody reacts with Human, Mouse samples. Supplied as 100 µg purified antibody (0.5 mg/mL).

Receiver operating characteristic curve analyses demonstrated that CD45RA (on granulocytes) and CD45RO (on lymphocytes) allow a good differentiation of volunteers and patients with sepsis (AUC = 0.9; p = 0.0001).

CD45RA contains exon 4 but lacks exon 5 and 6. It's expressed on naïve T cells. CD45RO contains exon 3, 7 and 8 and lacks the RA, RB and RC exons of the CD45 gene. CD45 isoforms with short extracellular domains homodimerize more …

1998年2月1日 · The CD45R hi revertant memory T cells are derived from the CD45R lo subset but are quiescent, resemble naive CD4 + T cells, show increased antigen-specific precursor frequency and have a capacity for long life.

2023年9月20日 · 2023年8月31日，宾夕法尼亚大学Saar Gill 教授、Carl June 教授研究团队在Science 子刊 Science Translational Medicine 上发表了题为Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy 的研究论文，该论文介绍了一种血液肿瘤治疗的新思路。 论文研究团队通过靶向泛造血干细胞谱系表达的CD45蛋白，尝试开发一种“血液肿瘤通用”的 CAR-T细胞疗法。

CD45RA is located on naive T cells and CD45RO is located on memory T cells. CD45 is also highly glycosylated. CD45R is the longest protein and migrates at 200 kDa when isolated from T cells. B cells also express CD45R with heavier glycosylation, bringing the molecular weight to 220 kDa, hence the name B220; B cell isoform of 220 kDa.