CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the …

CD47 renders malignant cells resistant to classic immune surveillance machinery and is now recognized as a fundamental driver of tumor growth. Under normal physiological conditions, …

cd47是sirpα最主要的配体，其它的配体包括：表面活性蛋白a和d（sp-a和sp-d）。目前sirpα被研究的最透彻的功能是其抑制巨噬细胞的吞噬功能； cd47分子和sirpα分子结构以及信号通路示 …

2022年9月1日 · The transmembrane protein, CD47, is recognized as an important innate immune checkpoint, and CD47-targeted drugs have been in development with the aim of inhibiting the …

2024年9月1日 · CD47 is highly expressed in cancers to prevent phagocytosis by phagocytes. Targeting CD47 has been verified as a promising therapeutic strategy in cancer …

CD47 is a transmembrane protein widely expressed in normal and tumoural cells; its receptor SIRPα is another ITIM-containing signalling protein, expressed on myeloid cells, especially …

2023年1月24日 · CD47 plays an important role in suppressing phagocytosis through binding to transmembrane protein SIRP-alpha on macrophages. Targeting CD47 is a novel strategy for …

By binding to another cell surface glycoprotein, signal regulatory protein alpha (SIRP α), CD47 can regulate the function of cells in the monocyte/macrophage lineage. In this spotlight paper, …

Here, we review the role of CD47 in the maintenance of immune system homeostasis. We also depict three emerging CD47-targeting strategies for cancer therapy, including the use of …

The use of anti-CD47 mAb to blockade CD47-SIRPα is a potential therapeutic strategy in the deadly duo of COVID-19 and cancer. Early detection of other signaling pathways such as anti …