2019年5月14日 · L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor.

CD62L/L-selectin is a marker found on naïve T cells and further distinguishes central memory (Tcm, CD62L+) from effector memory (Tem, CD62L−) T cells. The regulation of CD62L plays a pivotal role in controlling the traffic of T lymphocytes to and from peripheral lymph nodes.

2019年1月1日 · Accordingly, ILCs present in PB of CD patients have a strongly reduced expression of CD62L, further implicating CD62L as a functional marker for recirculating, nonactivated ILCs in both human and mouse and suggesting that CD62L expression on ILCP can potentially serve as a diagnostic marker in the clinic.

2019年1月1日 · We found that during homeostasis, ILCP in PB of mouse and human expressed homing receptors for secondary lymphoid organs, mainly CD62L. These ILCP entered mouse lymph nodes in a CD62L-dependent way and relied on S1P receptors for their exit.

2023年12月26日 · Hanson et al. show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 regulates memory B cell subset differentiation through control of a network of genes, including Bcl2 and Zeb2.

Antigen-experienced T cells have been divided into CD62L + CCR7 + central memory (T CM) and CD62L − CCR7 − effector memory (T EM) cells. Here, we examined coexpression of CD62L and CCR7 in lymphocytic choriomeningitis virus-specific memory CD8 T cells from both lymphoid and nonlymphoid tissues.

2021年12月14日 · Kurokawa and colleagues identify CD62L as a marker to reveal the heterogeneity of common myeloid progenitors (CMPs) and granulocyte-monocyte progenitors (GMPs) through gene expression analysis at single-cell levels.

2023年12月26日 · Overexpression of Zeb2 impairs the development of CD62L + memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations.

CD62L expression identifies a population of ILCp more biased toward type 2 profile. Circulating ILCp expressing CD62L are significantly reduced in psoriatic patients resulting in a skewing toward ILC3. Introduction

2012年1月1日 · Memory T cells (CD62L −) represent a population of T cells that have previously encountered pathogens and may contain fewer T cells capable of recognizing neoantigens including recipient allo-antigen (aAg). Human naive (CD62L +) or memory (CD62L −) T cells have different capacities to respond to aAg (Foster et al. 2004).