2016年11月21日 · CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and other mononuclear phagocytes. Traditionally, CD68 is exploited as a valuable cytochemical marker to...

CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).

CD68, also known as Gp110 or macrosialin, is a type I transmembrane glycoprotein of 110kDa. Pulford et al used the six antibodies discussed previously to evaluate expression of this protein in human blood, tissue and cell lines, and demonstrated that all …

通过免疫组化检测 CD68，可以确定组织中巨噬细胞的分布、数量和激活状态等信息。 例如，在炎症部位，巨噬细胞会大量聚集，CD68 的表达水平会升高，免疫组化染色后呈现出较强的阳性信号。 应用范围主要涵盖以下几类病症： 其一，在真性组织细胞性淋巴瘤的诊断与病情评估过程中发挥关键作用。 通过对病变组织进行相关检测，若 CD68 呈现特定的表达模式或水平变化，能够辅助医疗专业人员精准判断是否存在真性组织细胞性淋巴瘤，并且可以进一步监测疾病的进展程度 …

CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and other mononuclear phagocytes. Traditionally, CD68 is exploited as a valuable cytochemical marker to immunostain monocyte/macrophages in the histochemical analysis of inflamed tissues, tumor tissues, and other imm …

cd68是一种可以在单核细胞和巨噬细胞中高表达的跨膜糖蛋白。 虽然在造血细胞系中低表达，但可通过PMA/TPA对CD68进行诱导。 可以与组织和器官特异性凝集素或选择素结合，使巨噬细胞亚群归巢到特定部位。

In the inflammatory infiltrate several distinct cell types have been identified, but CD68+ macrophages are supposed to be most important. To investigate the collaboration among the various cell types within the infiltrate we performed at explanted meshes from humans double fluorescence staining with CD68 as a constant marker and a variety of ...

2025年2月8日 · CD68, a transmembrane glycoprotein, is predominantly expressed on macrophages and serves as a reliable marker for these immune cells. Its structure, characterized by a heavily glycosylated extracellular domain, facilitates its role in …

1 天前 · Additional studies utilizing immunofluorescence with CD11b, a pan myeloid marker and CD68, a marker for monocytes and macrophages 27,56,57,58 confirmed that navitoclax-induced apoptosis in these ...

2017年1月1日 · CD68 has been shown to bind oxLDL, phosphatidylserine, apoptotic cells and serve as a receptor for malaria sporozoite in liver infection. CD68 is mainly located in the endosomal/lysosomal compartment but can rapidly shuttle to the cell surface. However, the role of CD68 as a scavenger receptor remains to be confirmed.