We set out to create a DSM that would encompass most of the achievable differentiation states for splenic CD8 T cells in LCMV infection. The CD8 T cell responses to acute (Armstrong strain) and chronic (Clone 13 strain) LCMV infections peaks at day 8, then T cell numbers contract, stabilizing after day 30.

2025年3月7日 · In response to chronic infections and cancer, CD8 T cells differentiate into an exhausted T (T ex) cell phenotype that exhibits suboptimal effector activity.The transcription factor TOX is critical for T ex differentiation, but it is unclear whether TOX is necessary to maintain this cell state after it is established. Huang et al. inducibly ablated TOX from committed virus-specific T …

2025年1月16日 · 清华大学祁海教授团队在其新发表的论文“GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases”中，发现了慢性复发性气道炎症（如慢性鼻窦炎伴鼻息肉）中持续存在的新型CD8+效应记忆样T细胞可以通过表达胰蛋白酶Granzyme K（GZMK）激活补体级联反应，从而 ...

Resting naive CD8 + T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection.

Cell-cycle gene-expression analysis shows that suppressors of cell proliferation were significantly higher expressed in CD8 + T cells cultured alone (P5), whereas CD8 + T cells cultured with DCs without antigen (P1 and P3) had decreased expression of negative regulators and relatively moderate expression of positive regulators of the cell cycle ...

2025年3月14日 · In CD8 + T cells, relative QRICH1 ... Targeting QRICH1 function alone or in combination with existing checkpoint inhibitors should be investigated as an approach toward improving endogenous T cell responses in cancer immunity or the performance of engineered CAR-T cells, and our findings with the LM-Ova model suggest that such an approach would ...

4 天之前 · Instead, it significantly decreased the number of infiltrating CD8+ T cells compared to Y45 alone. This effect was even more pronounced with PC61 alone, which led to a nearly complete loss of infiltrating CD8+ T cells and poor survival rates (Figure 6A-B). Additionally, the number of effector T cells expressing perforin, IFN-γ, granzyme B, and ...

Partial activation of CD8 T cells, either in vitro or in vivo, with antigen and costimulation alone induces a brief abortive response, with poor induction of effector functions and potential deletion of the cells [14–16]. During the course of infections, different pathogen-associated molecular patterns and danger signals promote the ...

2025年1月27日 · Using a novel human tonsil immune organoid system, Chen et al. demonstrate that by controlling autoreactive humoral and cellular responses, human CD4 + regulatory T cells (T reg cells) and CD8 +...

4 天之前 · CD8 + cells that are Gzma + and Klrg1 + are often considered to be Short Lived Effector Cells (SLEC) so we will consider these to be SLEC-like. ... Gated cells represented as a proportion of CD3 + T cells in either clusters generated from variably expressed genes alone or variably expressed genes with T cell marker weighted principal components ...