CD8 - Wikipedia
The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail.
Differential expression of CD8 alpha and CD8 beta associated …
The differential expression of the alpha and beta chains of the CD8 glycoprotein was examined in three functionally distinct cytolytic effector cell populations: (i) T cells (CD3+ CD56-), (ii) NK cells (CD56+ CD3-), and (iii) non-MHC-restricted T cells (CD56+ CD3+).
Pathology Outlines - CD8
2023年8月24日 · Heterodimer of an alpha (CD8A, OMIM #186910) and a beta chain (CD8B, OMIM #186730) linked by two disulfide bonds; each chain has significant homology to immunoglobulin variable light chains; is present as a heterodimer on thymocytes and as homodimer on peripheral blood T cells
An immunological role for the CD8 beta-chain - PubMed
1992年5月21日 · Functional characterization of CD8 has focused primarily on the effect of the alpha-chain, which enhances or reconstitutes T-cell responses in homodimeric form and may play a specific role in thymic selection. In contrast, no role has been ascribed to CD8 beta or alpha beta heterodimers specifically.
CD8B CD8 subunit beta [Homo sapiens (human)] - Gene - NCBI
2024年11月27日 · Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or …
CD8 beta chain influences CD8 alpha chain-associated Lck kinase ...
1995年4月4日 · Recent studies indicate an important role for the CD8 beta chain in thymic development of CD8+ T cells and suggest that signaling via CD8 alpha beta may be distinct from CD8 alpha alpha. To better understand these differences, we introduced the CD8 beta gene into a T cell hybridoma which only expressed the CD8 alpha alpha homodimer.
An immunological role for the CD8 β-chain | Nature
1992年5月21日 · Here we show that CD8 αβ transfectants produce more interieukin-2 than CD8α transfectants in response to specific stimuli. Increased interleukin-2 is also observed in cells expressing hybrid...
Differential expression and regulation of the human CD8 alpha and CD8 …
Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The majority of monoclonal antibodies (mAb) reactive with the human CD8 antigen bind the CD8 alpha chain, while a single mAb, T8/2T8-5H7, has been identified which binds to the CD8 alpha/beta heterodimer.
Requirement for CD8 β Chain in Positive Selection of CD8 ... - AAAS
CD8 is either an αα homodimer or an αβ heterodimer, although most peripheral CD8-lineage T cells express only the CD8αβ heterodimer. The physiological function of CD8β was elucidated with mice that were chimeric for the homozygous disruption of the CD8β gene.
CD8αα and CD8αβ: truly different?: Trends in Immunology - Cell …
2002年4月1日 · In their investigation of the functional consequences of carbohydrate changes associated with T-cell differentiation in the thymus, Moody et al. [1] show that it is the β-chain of CD8 that modulates the binding of the Ig-like domain of the αβ heterodimer head to pMHC through the (O -linked) glycans on its stalk region, in such a way as to reorie...
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