2018年1月29日 · Growing evidence suggests that CD8+CD28- T cells are a unique subpopulation of regulatory T cells (Tregs) that exert broad effects on directly regulating T cells, such as by inhibiting their...

2022年8月24日 · CD8+CD28-调节性T细胞是缺乏CD28分子的一类CD8+T细胞，对T细胞的活化起负性调控作用，在控制自身免疫性疾病、器官移植后排异反应等方面发挥着重要的调节作用。 近年来研究证实，CD8+CD28-调节性T细胞是调节性T细胞的重要亚群，与CD4+CD25high Treg细胞一样具有免疫抑制功能。 CD8+CD28-Treg可诱导APC细胞表面IL-3、IL-4等抑制性抗体表达上调，使其处于免疫耐受状态；下调CD80、CD86等共刺激分子的表达，抑制Th细胞活性。 由 …

Results: It was found that in high-activity SLE patients, the CD8 + CD28 + T-cell subset was reduced, which was inversely correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and that the CD8 + CD28-/CD8 + CD28 + ratio was elevated, which was positively correlated with SLEDAI and with renal damage and inversely ...

细胞毒性T淋巴细胞（CTL细胞）通常称为CD8 + T细胞，是适应性免疫系统的关键组成部分，在免疫系统抵御病原体（如病毒、细菌和肿瘤）中发挥重要作用 [1]。 辅助性CD4 + T细胞（如 Th1 、Th2、Th9、 Th17 、Th22、 Tfh 和 Treg）是在胸腺中生成并表达αβ-T细胞受体或TCR，但与CD4 + T细胞不同的是它们的表面表达CD8 ，并且对MHC I类的外源性抗原反应。 Naive/静息CD8 + T细胞能够扩增和分化为细胞毒性效应细胞，监视机体并清除感染。 若缺失CD8 + T细胞 ，机体 …

There is growing evidence that the CD8 + CD28 − (CD8 + CD57 +) T-cell population plays a significant role in various diseases or conditions, associated with chronic immune activation such as cancer, chronic intracellular infections, chronic alcoholism, some chronic pulmonary diseases, autoimmune diseases, allogeneic transplantation, as well as h...

2019年9月2日 · 人类cd8＋ t细胞亚群根据cd27、cd28、ccr7、cd45ra的表达，定义出五种不同的循环cd8＋t细胞亚群。 下图中展示了五个亚群之间不同的相对端粒长度、各种细胞表面受体和细胞内分子的表达（与T细胞活…

2024年12月11日 · cd28-cd57+ 这些细胞在失去cd28并获得cd57后，通常会呈现渐进性变化。 Strioga等人质疑了此前将CD8+CD28-/CD57+细胞视为“衰老性”的传统观点，指出在特定条件下，这些细胞依然具备增殖能力。

2025年3月14日 · We stimulated WT mouse primary CD8 + and CD4 + T cells for 24 hours with anti-CD3/CD28 and assessed QRICH1 protein levels via protein immunoblot. In CD8 + T cells, relative QRICH1 protein levels were increased up to 14.5-fold in stimulated cells compared with unstimulated cells, indicating that QRICH1 protein expression is up-regulated within ...

2 天之前 · Various CD8 + non-Foxp3 regulatory T cells (Tregs) have been described in humans and mice, such as CD122 + CD8 + T cells, CD28 low CD8 + T cells, CD103 + CD8 + T cells, Ly49 + CD8 + T cells, CD8 + T Ab-supp cells, and CD8αα + CD4 – T cells, as well as other CD8 Tregs induced with B cells in vitro or via plasmacytoid dendritic cells.

2024年6月3日 · Cessation of elotuzumab treatment during consolidation/maintenance after initial therapy during induction (i.e., Elo-RVd/R) resulted in a rise in the levels of effector and regulatory CD8 + T ...