A cytotoxic T cell (also known as T C, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8 + T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens such as viruses or bacteria, or cells that are damaged in other ways.

2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire...

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.

细胞毒性T淋巴细胞（CTL细胞）通常称为CD8 + T细胞，是适应性免疫系统的关键组成部分，在免疫系统抵御病原体（如病毒、细菌和肿瘤）中发挥重要作用 [1]。 辅助性CD4 + T细胞（如 Th1 、Th2、Th9、 Th17 、Th22、 Tfh 和 Treg）是在胸腺中生成并表达αβ-T细胞受体或TCR，但与CD4 + T细胞不同的是它们的表面表达CD8 ，并且对MHC I类的外源性抗原反应。 Naive/静息CD8 + T细胞能够扩增和分化为细胞毒性效应细胞，监视机体并清除感染。 若缺失CD8 + T细胞 ，机体 …

Resting naive CD8 + T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection.

2023年10月10日 · CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell effector function. Here, we review the current understanding of T cell function in cancer, focusing on key CD8 + T cell subtypes and states.

What are cytotoxic T cells? Cytotoxic T lymphocytes (CTLs) often called CD8 + T cells, are a critical component of the adaptive immune system and play an important role in immune defense against intracellular pathogens such as viruses and bacteria and against tumors [1].

2021年5月12日 · Cytotoxic CD8 + T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 + T...

2022年4月12日 · CD8 + T 细胞亚群和功能介绍如下： 迄今为止，已经鉴定了几个 CD8 + Tc 亚群，包括产生 IFN-γ 的传统 Tc1s、产生 白细胞介素 -4(IL-4)的Tc2s 、产生 IL-9 的Tc9s 、产生 IL-17 的Tc17s 和产生 IL-22的Tc22s 。 naïve CD8+ T cells分化成各种不同的 Tc 亚群

2025年1月16日 · 清华大学祁海教授团队在其新发表的论文“GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases”中，发现了慢性复发性气道炎症（如慢性鼻窦炎伴鼻息肉）中持续存在的新型CD8+效应记忆样T细胞可以通过表达胰蛋白酶Granzyme K（GZMK）激活补体级联反应，从而 ...