The lymphocyte surface CD8 antigen is a heterodimer with each chain containing a single Ig-related domain, a hinge-like sequence, a transmembrane segment, and a short cytoplasmic sequence. A soluble form of the rat CD8 alpha chain was produced by introducing a stop codon into the cDNA at the end of …

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell - antigen interactions.

1998年10月1日 · First, the dimer of the Ig-like domains of CD8 is the biologically relevant unit that binds the MHC α3 CD loop in an antibody-like manner. Second, the stalk regions that link this recognition unit to the transmembrane segments of the two CD8α chains must bend substantially, presumably near the C-termini of the Ig domains, such that the β ...

2005年9月2日 · CD8 is expressed either as a CD8αβ heterodimer or a CD8αα homodimer on the T cell surface (Carrasco et al., 1999; Cawthon et al., 2001; de Totero et al., 1992; Konno et al., 2002; Moebius et al., 1991; Terry et al., 1990). Although both dimers can serve as a coreceptor for T cell activation and differentiation, they are different in several ...

2016年4月28日 · Hereby, we resolved the crystal structures of chicken, swine and bovine CD8αα. They are typical homodimers consisting of two symmetric IgV domains with distinct species specificities. The CD8αα...

Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T cells that contributes to antigen recognition, immune cell maturation, and immune cell signaling. While CD8 is widely recognized as a co-stimulatory molecule ...

Structural Basis of CD8 Coreceptor Function Revealed by Crystallographic Analysis of a Murine CD8aa Ectodomain Fragment in Complex with H-2Kb pMHC-I complex. These findings are consistent with prior observations showing linkage between the CD8 and CD4 phenotypes of T cells and their specificities for pMHC-I versus pMHC-II complexes, respectively

CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers.

There are two forms of CD8, either as an αα homodimer or αβ heterodimer. It acts as an “assistant” or co-receptor in the function of cytotoxic T cells where specific immunity is mediated by...

1994年3月1日 · The CD8 dimer interacts with the alpha 3 domain of major histocompatibility complex class I molecules through two immunoglobulin variable-like domains. In this study a crystal structure-informed mutational analysis has been performed to identify amino acids in the CD8 alpha/alpha homodimer that are …