Cytotoxic CD8+ T cells promote granzyme B-dependent adverse …
2021年3月5日 · Here, we show that following acute myocardial infarction in mice, CD8 + T lymphocytes are recruited and activated in the ischemic heart tissue and release Granzyme B, …
Granzyme K+CD8+ T cells interact with fibroblasts to promote ...
2024年11月29日 · Using single-cell analysis, spatial transcriptomics, and T-cell receptor sequencing, we identify an increased presence of granzyme K + (GZMK +) CD8 + T cells in …
Granzyme B + CD8 + T cells with terminal differentiated effector ...
2023年6月2日 · Our study mapped peripheral immune cells of RRMS and SPMS patients and provided an evidence for the involvement of GzmB + CD8 + T EMRA cells in the progression …
Granzyme B in circulating CD8+ T cells as a biomarker of
2022年11月9日 · Our study support the involvement of GzmB-expressing CD8+ T cells in the inflammatory response in patients with NMOSD and provide a potential biomarker for disease …
Granzyme K+ CD8 T cells form a core population in inflamed
2022年6月15日 · Using GzmK and GzmB signatures, we found that GzmK-expressing CD8 T cells were also the major CD8 T cell population in the gut, kidney, and coronavirus disease …
Frontiers | Granzyme B in circulating CD8+ T cells as a biomarker …
2022年11月8日 · Clinical correlation analysis indicated that high levels of GzmB in CD8+ T cells were not only related to severe disability but also significantly associated with increased serum …
Granzyme K+ CD8 T cells form a core population in inflamed …
Using T cell receptor repertoire data, we found that CD8 GzmK + GzmB + T cells are clonally expanded in synovial tissues and maintain their granzyme expression and overall cell state in …
KLF2 maintains lineage fidelity and suppresses CD8 T cell ... - AAAS
CD8 T cells within a population responding to signs of disease can form several discrete states with distinct functional properties. Fagerberg et al. combined CRISPR/Cas9-gene editing with …
Continuous expression of TOX safeguards exhausted CD8 T cell
2025年3月7日 · In response to chronic infections and cancer, CD8 T cells differentiate into an exhausted T (T ex) cell phenotype that exhibits suboptimal effector activity.The transcription …
Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by …
3 天之前 · Differential gene expression analysis revealed that YD treatment substantially increased the expression of genes involved in cytotoxic cytokine secretion, such as Gzma, …