2023年8月3日 · Fecci and colleagues show that tumor cells having lost MHC-I, a major mechanism of immune escape, are amenable to killing by CD8+ T cells through an MHC-I …

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, …

Here, we report that CD8 + T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression. This capacity proves to be dependent instead on interactions between T …

2025年4月1日 · As a pivotal member of T cell subsets, CD8 + T cells play a central role in the antitumor immune response. They can regulate the functions of other immune cells either by …

2023年8月3日 · CD8+ T cells recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. How CD8+ T cells eliminate cancer cells …

2020年12月1日 · We demonstrated that splenocytes and tumor-infiltrating T cells derived from mice treated with combination therapy were able to kill approximately 50% of target cells after …

2025年1月14日 · 作者从21种肿瘤病人中筛选到小鼠中缺失而人具有的转录因子ETV7，是驱动CD8+ T细胞命运向耗竭转化的核心，且广泛存在不同肿瘤中。 临床前免疫治疗研究发现，靶 …

2024年4月29日 · CD8 + T cells can form immune synapses with target cells after activation. Subsequently, CD8 + T cells release granzymes, perforin, and cytokines to destroy tumor …

1 天前 · The new research findings, supported by funding from the National Institutes of Health, were published March 14 in Science Immunology. The protein QRICH1 is a recently identified …

3 天之前 · The infiltrated cells were sorted by flow cytometry for in vitro tumor cell killing assays or in vivo cell infusion therapy combined with chemotherapeutic drugs and immune checkpoint …