2008年12月1日 · These studies ascribe multifaceted functions specific to Erk2 in CD8 T cell activation, proliferation, and survival. The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK pathway plays a critical role in these cell fate decisions within CD8 T cells.

MAPK级联在细胞增殖、凋亡等多种细胞过程中具有双向调控的作用，具体取决于细胞类型、刺激物以及刺激时间的长短。 通常情况下，ERK的激活能够促进细胞存活，即通过转录和翻译后机制上调Bcl-2、Bcl-xL、Mcl-1、IPA等抗凋亡蛋白，下调Bad、Bax、Bim和Bmf等促凋亡蛋白来阻止细胞凋亡。 但当ERK受损伤因素或抗肿瘤药物等刺激被激活，则可诱导线粒体释放细胞色素c，激发内在凋亡途径；也可通过激活胱天蛋白酶-8 (caspase-8)，诱发外在凋亡途径 [2]。 DNA损伤导 …

2024年10月23日 · We found that long-term focal adhesion kinase (FAK) inhibitor treatment led to hyperactivation of the RAS/MAPK pathway in PDAC cells in mouse models and tissues from patients with PDAC.

2021年9月17日 · We uncover a conserved, MAPK/IRF1-mediated inflammatory response in tumors that undergo stemness- and senescence-associated reprogramming. In these tumor cells, activation of the innate immunity...

2023年8月15日 · CD8 + T cells, commonly known as cytotoxic T lymphocytes, are critical for immune system-mediated defense against pathogens, including viruses and bacteria, as well as for tumor cell...

We now demonstrate that the Erk MAPK pathway plays a critical role in these cell fate decisions within CD8 T cells. While Erk1 is dispensable for all aspects of CD8 T cell activation, Erk2 is required for the proliferation of CD8 T cells activated in the absence of costimulation.

We show here that MEK inhibition did profoundly block naive CD8 + T cell priming in tumor-bearing mice, but actually increased the number of effector-phenotype antigen-specific CD8 + T cells within the tumor. MEK inhibition protected tumor-infiltrating CD8 + T cells from death driven by chronic TCR stimulation while sparing cytotoxic activity.

1997年11月1日 · Based on the mechanisms of fate specification known for simple metazoan organisms, we sought to determine whether the extracellular signal-related kinases (ERKs) play a role in T cell differentiation and lineage commitment. Using a dominant gain-of-function mutant of the erk2 gene, we show that differentiation into the CD4 lineage is favored.

2015年9月8日 · 摘要： 目的 探讨丝裂原活化蛋白激酶（MAPK）信号通路在卵巢癌细胞（SKOV3）诱导CD8+Treg分化过程的作用。 方法 建立SKOV3与健康人CD8+ T细胞体外共培养体系，设置CD8+T细胞单独培养组为对照组。

Erk2-deficient CD8 T cell survival can be rescued by genetic ablation of Bim. These studies ascribe multifaceted functions specific to Erk2 in CD8 T cell activation, proliferation, and survival.