细胞毒性T淋巴细胞（CTL细胞）通常称为CD8 + T细胞，是适应性免疫系统的关键组成部分，在免疫系统抵御病原体（如病毒、细菌和肿瘤）中发挥重要作用 [1]。

2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens such as viruses or bacteria, or cells that are damaged in other ways.

2020年9月15日 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.

2024年11月29日 · CD8 + T cells have a pivotal role in adaptive immune responses, recognizing antigen peptides through the T cell receptor (TCR) and eliminating infected or malignant cells 1. These cells exhibit...

CD8+T细胞又被称为细胞毒性T淋巴细胞（Cytotoxic Tlymphocyte，CTL），是T细胞表面表达CD8亚群的一类细胞，作为一种二聚体受体，可使CD8+T细胞识别MHC I类蛋白呈递的肽。所有T细胞均起源于从骨髓迁移至胸腺的淋巴…

CD8分子是MHCI类限制性T细胞识别抗原的辅助受体，能够与 MHCI类分子 结合而辅助TCR识别其递呈的抗原，并增强 T细胞 与 抗原提呈细胞 (APC)或 靶细胞 之间的相互作用。

2025年3月18日 · Background In recent years, immunotherapy has made significant progress. However, the understanding of the heterogeneity and function of T cells, particularly CD8 + T cells, in cervical cancer (CESC) microenvironment remains insufficient. We aim to characterize the heterogeneity, developmental trajectory, regulatory network, and intercellular communication of CD8 + T cells in cervical squamous ...

2025年3月11日 · Generating balanced populations of CD8 + effector and memory T cells is necessary for immediate and durable immunity to infections and cancer. Yet, a definitive understanding of how a diverse CD8 + T cell repertoire differentiates remains unclear.

2025年3月20日 · Explore the role of CD8 activation markers in T-cell function, their expression across tissues, and methods for assessing immune responses in different contexts.