专家点评 | 3篇Nature1篇Nat Immuno揭示调控耗竭CD8+T细胞的 …
本文发现，tox在功能障碍的肿瘤特异性cd8+t细胞中高表达，且tox的表达需要慢性的tcr刺激和nfat的激活。在体外效应t细胞中过表达tox可在转录水平上诱导出耗竭相关变化。相反，tst …
3篇Nature，揭示TOX蛋白在调节免疫T细胞功能的关键作用_光谱网
2 天之前 · John Wherry团队在Nature 在线发表题为“TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion”的研究论文，研究人员将HMG-box转录因子TOX鉴定为TEX …
Continuous expression of TOX safeguards exhausted CD8 T cell
2025年3月7日 · In response to chronic infections and cancer, CD8 T cells differentiate into an exhausted T (T ex) cell phenotype that exhibits suboptimal effector activity. The transcription …
TOX transcriptionally and epigenetically programs CD8+ T cell ...
Exhausted CD8 + T (T ex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared …
TOX transcriptionally and epigenetically programs CD8 - Nature
2019年6月17日 · Exhausted CD8 + T (T ex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional …
单细胞转录组和表观组学图谱揭示效应、记忆和耗竭CD8 T细胞在 …
2022年3月27日 · 我们查看了CD8 T细胞分化的3个关键基因：Tox，Pdcd1和Tcf7。 其中，Tox是Tex细胞分化的一个关键转录因子，在慢性感染C13样本的不同时间点中它的表达水平都很 …
TOX is expressed by exhausted and polyfunctional human effector memory CD8
Using bulk and single-cell transcriptome analyses and flow cytometric analyses, Sekine et al. have generated a detailed map of TOX and TCF-1 expression in human CD8 + T cells. TOX is …
Single-cell RNA-seq reveals TOX as a key regulator of CD8 - Nature
2019年6月17日 · In this study, we have shown that Tox deficiency led to defects in the long-term persistence of antiviral CD8 + T cells and a loss of progenitor-like CD8 + T cells, and that TOX...
Continuous expression of TOX safeguards exhausted CD8 T cell
2025年3月7日 · Although checkpoint blockade temporarily improves exhausted CD8 T (T ex ) cell function, the underlying T ex epigenetic landscape remains largely unchanged, preventing …
TOX is a critical regulator of tumour-specific T cell ... - Nature
2019年6月17日 · We show that TOX is highly expressed in dysfunctional TST cells from tumours and in exhausted T cells during chronic viral infection. Expression of TOX is driven by chronic …