2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就有人研究，然而，由于缺乏特异性标志物和基因表达调节分子，导致该研究方向一度被放弃。

2021年8月17日 · CD8 + Tregs perform their regulatory function by killing antigen activated CD4 + T cells and T FH cells. The main cytotoxic molecule shown to be important for CD8 + Treg function is perforin. CD8 + Treg from Prf1-/-mice were not able to suppress antigen-activated T FH cells in Rag2-/-mice .

2025年2月17日 · 本研究采用人类扁桃体类器官（tonsil organoid）模型，结合CRISPR-Cas9基因编辑技术，分别敲除CD4+ Treg的FOXP3基因和CD8+ Treg的GZMB（granzyme B）基因，以研究这两类Treg在调控自身免疫反应中的不同功能。

2023年11月1日 · The diverse subsets of CD8 T cells, including Tc1 cells, Tc2 cells, Tc9 cells, Tc17 cells, Tc22 cells, Tfcs, and suppressive CD8 Tregs, have emerged as critical players in immune responses...

We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of individual CD8 + T-cell subsets with proposed regulatory capacity separately.

Recent studies of these lymphocytes, now popularly referred to as regulatory CD8+ T cells (CD8+ Tregs), have helped clarify their important role in the regulation of autoimmune disease. Here, we review progress related to the identification, phenotype and function of CD8+ Tregs.

2025年3月19日 · To assess the effects of Y45 on Tregs independent of CD8+ T cells, we depleted CD8+ T cells in C57BL/6 mice by administration of a CD8-targeted antibody (clone 2.43). By day 9, CD8+ T cells were fully depleted, as confirmed by flow cytometry, attributed to antibody-dependent cell-mediated cytotoxicity (ADCC) ( Figure 2A,B ), enabling us to ...

2025年3月19日 · Various mammalian CD8+ T cell subsets with regulatory properties are either formed through a thymus-dependent mechanism or induced under various experimental protocols and referred to as CD8+ regulatory T cells (Tregs). CD8+ Tregs maintain distinct functions in the presence of CD4+ Tregs. This review focuses on the Foxp3+CD8+ Treg subset, which is typically extremely rare in unmanipulated mice ...

2025年3月10日 · Tissue-resident CD4 + T helper cells play a supportive role in generating CD8 + T RM cells, potentially through the secretion of cytokines like IL-21, which can promote the survival and function of CD8 + T cells . Type 1 Treg cells have also been implicated in the generation of CD8 + T RM cells.

CD8 + Treg are loosely defined as a heterogenous population of CD8 + lymphocytes that can express several Treg associated surface markers and have immunosuppressive capacity, thus defining them as a Treg subset (131–133).