敲除Cd80基因的exon 2-3 区域，获得Cd80基因敲除小鼠模型。 *使用本品系发表的文献需注明: Cd80-KO mice (Cat. NO. NM-KO-190184) were purchased from Shanghai Model Organisms Center, Inc.. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。 常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小 …

Cd80-KO小鼠模型是由赛业生物（Cyagen）采用基因编辑技术构建的全身性基因敲除小鼠。 Cd80基因位于小鼠16号染色体上，由5个外显子组成，其中ATG起始密码子在1号外显子，TAG终止密码子在5号外显子。

You can quickly query the required genetically engineered global knockout (KO) mouse, conditional knockout (cKO/floxed) mouse and microRNA KO mouse strains by simply entering the gene name.

Human Ortholog CD80 Human Ortholog Associated Diseases by GWAS 乳糜泻、肝硬化 Model Description 敲除Cd80基因的exon 2-3 区域，获得Cd80基因敲除小鼠模型。 Research Application：免疫相关 *Literature published using this strain should indicate: Cd80-KO mice (Cat. NO. NM-KO-190184) were purchased from Shanghai Model ...

研究发现，食管癌、胃癌、子宫内膜样癌组织中DC细胞表面CD80和CD86的表达水平显著下调，导致DC功能缺陷，不能有效的激活抗肿瘤免疫，引起肿瘤的免疫逃逸。 CD80和CD86的表达水平是临床病理分期和预后的重要指标，也是非常有潜力的免疫治疗靶点。 阿巴西普（Abatacept）是FDA批准上市的靶向CD80和CD86的药物，用于治疗微小病变性肾病、类风湿关节炎、系统性红斑狼疮等疾病。 它是一个融合蛋白，包含CTLA-4的胞外结构域与人IgG1蛋白 …

In this study, we specifically investigated the role of PD-L1/CD80 signaling in limiting the survival of activated CD8 + T cells. During an immune response, activated CD8 + T cells go through a period of expansion; then, after antigen clearance, there is a contraction phase during which a majority of the activated CD8 + T cells die by apoptosis.

2019年5月9日 · This study provide evidence for a major role of CD80 in orchestrating immune surveillance of colon preneoplastic lesions and might help to develop novel approaches that exploit anti-tumor immunity to prevent and control colon cancer.

CD80 KO cell line available to order. KO validated by Next Generation Sequencing. Free of charge wild type control provided.

CD80 also known as B7-1 is a cell surface protein with a molecular weight of approximately 60 kDa. It is expressed on antigen-presenting cells such as dendritic cells macrophages and B cells. The CD80 protein plays a mechanical role in immune response modulation by providing necessary signals for T cell activation and survival.

2007年12月12日 · Our results indicated that while none of the adjuvant formulations that we studied can bypass the requirement for CD80 and CD86-mediated signaling (i.e. CD80/86 double KO mice) to potentiate antibody responses, several formulations demonstrated a preference for CD86 or CD80 co-stimulation to exert adjuvanticity.