CD81 Is Essential for the Re-entry of Hematopoietic Stem Cells to ...
2011年9月13日 · Treatment of Cd81-deficient HSCs with an Akt inhibitor, perifosine, which bypasses the requirement for CD81 in this process, rescues the delay defect of Cd81-deficient …
Transient activation of AKT by HCV. A , Huh7.5 cells
CD81 and Claudin-1 —The observation that the AKT activation was detected as early as 15 min and peaked by 30 min after HCV infection indicated the involvement of an early HCV infection …
CD81 Promotes a Migratory Phenotype in Neuronal-Like Cells
CD81 overexpression increased the number of cells with a migratory phenotype, in a potentially phosphatidylinositol 3 kinase (PI3K)-Ak strain transforming (AKT) mediated manner. Indeed, …
四次跨膜蛋白CD81：丙型肝炎病毒（HCV）关键受体，外泌体重 …
2023年12月22日 · 进一步研究揭示，cd81通过akt依赖的sp1激活信号通路诱导mt1-mmp的表达，进而刺激黑色素瘤细胞的运动，增加黑色素瘤的侵袭和转移 [23-24] 。此外，cd81的缺失也 …
CD81 is essential for the re-entry of hematopoietic stem cells to ...
Here, we show that lack of CD81 leads to loss of HSC self-renewal, and the clustering of CD81 on HSC membrane results in deactivation of Akt, which subsequently leads to nuclear …
Pax5 mediates the transcriptional activation of the CD81 gene
2021年11月25日 · CD81 membrane protein promotes melanoma cell motility by inducing metalloprotease MT1-MMP expression through the Akt-dependent Sp1 activation signaling …
CD81, a new actor in the development of preeclampsia
2021年5月12日 · CD81 exerts a wide range of regulatory effects on immune cells. In B cells, CD81 facilitates the assembly of CD19-CR2/CD21 and B-cell receptor complexes at …
CD81 Is Essential for HSC Self-Renewal through Suppressing ...
2008年11月16日 · In addition, clustering of CD81 on the HSC cell membrane using a monoclonal antibody rapidly induced a quiescent phenotype. This was found to be associated with an …
CD81, also called TAPA-1, is a type III transmembrane protein that is broadly expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. CD81 is believed to be involved …
The Tetraspanin CD81 Protein Increases Melanoma Cell Motility …
2014年5月5日 · Results: CD81-Akt signaling induces Sp1-mediated MT1-MMP expression, which enhances melanoma cell motility and invasiveness. Conclusion: CD81 functions as an inducer …