2023年12月22日 · CD81（又名Tetraspanin-Associated Protein 1，TAPA-1）是首个被认定的HCV感染靶细胞的受体分子，最初是在筛选能抑制B淋巴细胞瘤增殖的单克隆抗体的过程中被发现的，属于四次跨膜蛋白超家族（Tetraspanins/TM4SF）（点击了解“ 什么是TM4SF家族 ”）。 CD81由四个跨膜区、两个胞浆区（N端和C端），以及一个胞外结构城（EC）构成。 其中，EC分为EC1和EC2，分别由28和80个氨基酸残基组成。 EC1位于跨膜区TM1与TM2之间，形成了 …

Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In this review, we detail the current knowledge on the involvement of CD81 in the HCV lifecycle, as well …

2018年7月19日 · Our findings reveal a comprehensive CD81 network in human liver cells and show that HCV and Plasmodium highjack selective CD81 interactions, including CAPN5 and CBLB for HCV, to invade cells. CD81 is a cell membrane protein, which functions as entry factor for hepatitis C virus (HCV) and malaria sporozoites in the human liver.

2021年9月15日 · Crystal structures of the hepatitis C virus (HCV) glycoprotein E2 in complex with CD81 reveal the conformational changes that occur in E2 after binding of CD81 and the effects of pH on...

CD81是四跨膜蛋白超家族（TM4SF）成员之一，可以与其他四跨膜蛋白、整合素、辅助受体、MHC I类或II类分子形成复合物，影响B、T细胞的粘附、形态、激活、增殖和分化。

2024年1月31日 · CD81 was downregulated at the mRNA level in hepatoma cells that replicate HCV. Kinetics of HCV expression were increased in CD81-knockout cells and accompanied by enhanced cellular growth. Furthermore, loss of CD81 compensated for inhibition of pro-survival TBK1-signaling in HCV expressing cells.

CD81 also plays a crucial role in pathogen entry into host cells, including hepatitis C virus (HCV) entry into hepatocytes. HCV is a major cause of liver cirrhosis and hepatocellular carcinoma.

Several cellular molecules have been identified as putative receptors for Hepatitis C virus (HCV): CD81 tetraspanin, scavenger receptor class B type I (SR-BI), mannose-binding lectins DC-SIGN and L-SIGN, low-density lipoprotein receptor, heparan sulphate proteoglycans and the asialoglycoprotein rece …

CD81 serves as an immune modulator, playing its role in tumor growth and metastasis of hepatitis C virus (HCV)-mediated hepatocellular carcinoma (HCC). CD81 serves as a coreceptor of viral entry and is found to be enriched in exosomes. HCV E2 protein when associated with CD81 may be responsible for …

2020年10月13日 · 丙型肝炎病毒（HCV）通过多步机制进入人类肝细胞，其中包括宿主蛋白以及其他病毒受体CD81。 作者利用定量蛋白质组学，以识别HCV触发的CD81相互作用，并找到26个动态结合蛋白质。 如RNAi所示，这些蛋白质中至少有六种会促进HCV感染。 作者进一步表征了血清反应因子结合蛋白1（SRFBP1），该蛋白在HCV摄取期间被募集至CD81，它与CD81形成复合物并支持HCV在肝癌细胞和原代人肝细胞中的感染。 因此，SRFBP1是HCV特异性的泛基因型 …