2022年10月1日 · In this study, we provide the first indication that accumbal CD81 expression is essential for voluntary ethanol intake and preference in mice, as we show that shRNA-expressing lentiviral-mediated knockdown of CD81 mRNA in the Nacc impairs ethanol intake.

Anti-CD81 antibodies downregulate HIV production 3 fold, however the CD81 protein free virus is more infectious. [13] Engagement of CD81 lowers the signaling threshold required to trigger T-Cell\CD3 mediated proviral DNA in CD4+ T cells. [14] CD81 appears to play a role in the pathogenesis of influenza. [15]

2024年12月24日 · CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency. Among its related pathways are Complement cascade and Innate Immune System. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding.

CD81-protein interactions can be modulated with molecules targeting the extracellular domain of CD81, investigated as antiviral and/or anticancer agents. Several monoclonal antibodies anti-CD81 have been developed, notably mAb 5A6 active against invasion and metastasis of triple-negative breast cancer cells.

2024年12月10日 · Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB, NFAT, and AP-1 transduction pathways.

2024年3月7日 · Bulk RNA sequencing results after sorting CD81 high CD82 high and CD81 low CD82 low T cells consistently supported the roles of CD81 and CD82. Experiments with overexpressed CD81 and CD82 showed increased cytotoxicity against target cells.

2019年9月7日 · CD81 is a 26 kDa member of the tetraspanin family and is expressed in various types of cells. Experiments using CD81-knockout mice have shown that CD81 is not essential for the development of T and B lymphocytes, but may play an important role in the proliferation and proper immune response of B cells [7, 8].

2011年11月18日 · Expression of CD81 in MM-PC is an independent prognostic factor for patients with symptomatic MM and a marker for risk of progression in SMM. Blockage of CD81 with anti-CD81 antibodies does not show significant anti-myeloma activity; therefore, the precise mechanism of CD81 activation of MM-PC deserves further investigations.

2023年12月22日 · CD81（又名Tetraspanin-Associated Protein 1，TAPA-1）是首个被认定的HCV感染靶细胞的受体分子，最初是在筛选能抑制B淋巴细胞瘤增殖的单克隆抗体的过程中被发现的，属于四次跨膜蛋白超家族（Tetraspanins/TM4SF）（点击了解“ 什么是TM4SF家族 ”）。 CD81由四个跨膜区、两个胞浆区（N端和C端），以及一个胞外结构城（EC）构成。 其中，EC分为EC1和EC2，分别由28和80个氨基酸残基组成。 EC1位于跨膜区TM1与TM2之间，形成了 …

2012年10月3日 · Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering …