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Wikipedia
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CD83 - Wikipedia
CD83 (Cluster of Differentiation 83) is a human protein encoded by the CD83 gene. The membrane-bound form of CD83 consists of an extracellular V-type immunoglobulin-like domain, a transmembrane domain and a cytoplasmic signaling tail. A free soluble form consists of the immunoglobulin-like domain alone. Membrane-bound CD83 is expected to form trimers. Soluble CD83 is ab…
Gene
The CD83 gene is located on human chromosome 6p23 and mouse chromosome 13. In humans, a promoter 261 … 展开
Function
The transmembrane domain of membrane-bound CD83 stabilizes MHC II, costimulatory molecules and CD28 in the membrane by antagonizing MARCH-family E3 ubiquitin ligases.
It is not clear wh… 展开
See also
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CD83: Activation Marker for Antigen Presenting Cells and Its ...
CD83 is a member of the immunoglobulin superfamily and a marker of activated a…
Frontiers
The CD83 Molecule – An Important Immune Checkpoint - Frontiers
CD83 is a membrane protein expressed on activated immune cells that regulates …
Frontiers
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CD83 Gene - GeneCards | CD83 Protein | CD83 Antibody
2024年12月24日 · CD83 is a protein coding gene that encodes a membrane protein involved in antigen presentation and lymphocyte activation. It is located on chromosome 6 and has three transcript variants. See aliases, disorders, …
Frontiers
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CD83: Activation Marker for Antigen Presenting Cells …
2019年6月6日 · CD83 is a member of the immunoglobulin superfamily and a marker of activated antigen presenting cells. This article discusses the structure, expression, function and applications of CD83 in various immune diseases …
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Frontiers | The CD83 Molecule – An Important Immune Checkpoint
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Frontiers | The CD83 Molecule – An Important Immune Checkpoint
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Frontiers | CD83 expressed by macrophages is an important immune checkpoint molecule for the ...
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Peripheral function of CD83. (a) 'Normal' signaling through a putative... | Download Scientific ...
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Frontiers | CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential
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Frontiers | Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic Cells Provides ...
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Frontiers
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The CD83 Molecule – An Important Immune …
CD83 is a membrane protein expressed on activated immune cells that regulates tolerance and inflammation. Learn about its gene structure, promoter, signaling pathways, and therapeutic potential in this review article.

PubMed
https://pubmed.ncbi.nlm.nih.gov
The CD83 Molecule - An Important Immune Checkpoint
2020年4月17日 · The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and …
- 作者: Linda Grosche, Ilka Knippertz, Christina König, Dmytro Royzman, Andreas B Wild, Elisabeth Zinser, He...
- Publish Year: 2020
Nature
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Microglial expression of CD83 governs cellular activation and
2023年8月1日 · The prolonged expression of Cd83 in spinal cord microglia suggests that Cd83 is not only associated with acute activation but also with a reparative phenotype during the …
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Which cell types express CD83 molecule?
Collectively, the CD83 molecule is expressed by a great variety of cell types, but mainly by activated immune cells like DC, B- and T cells as well as by thymus epithelial – and tumor cells. In the following section of this review, we will now highlight the proposed functions of CD83 among the different cell types.
The CD83 Molecule – An Important Immune Checkpoint - Frontiers
frontiersin.org
Is CD83 a soluble or soluble immunoglobulin?
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostasis.
CD83: Activation Marker for Antigen Presenting Cells and Its
frontiersin.org
Where is the CD83 molecule found?
3 Division of Biotechnology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
The CD83 Molecule - An Important Immune Checkpoint
pubmed.ncbi.nlm.nih.gov
Where is CD83 stably expressed?
Cao W, Lee SH, Lu J. CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem J. (2005) 385 (Pt 1):85–93. doi: 10.1042/BJ20040741
CD83: Activation Marker for Antigen Presenting Cells and Its
frontiersin.org
Is CD83 a protein coding gene?
CD83 (CD83 Molecule) is a Protein Coding gene. Diseases associated with CD83 include Neonatal Infective Mastitis and Plague. Among its related pathways are Dendritic Cells Developmental Lineage Pathway and Macrophage markers. May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
CD83 Gene - GeneCards | CD83 Protein | CD83 Antibody
genecards.org
Which cells upregulate CD83?
CD83 is a member of the immunoglobulin superfamily and highly expressed in mature dendritic cells to function as one of the costimulation and adhesion molecules 20. Although activated T cells also upregulate CD83 21, its expression dynamics has not been elucidated in detail.
CD83 expression characterizes precursor exhausted T cell ... - Nature
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PubMed
https://pubmed.ncbi.nlm.nih.gov
CD83: Activation Marker for Antigen Presenting Cells and Its ...
2019年6月7日 · Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 …
百度百科
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cd83 - 百度百科
cd83是树突状细胞的特异性标志，参与抗原呈递和淋巴细胞活化。 CD83可用来鉴定和分离血中树突状细胞、滤泡连接细胞和郎格汉斯细胞。新手上路
Nature
https://www.nature.com › articles
CD83 expression characterizes precursor exhausted T cell ... - Nature
2023年3月11日 · CD83, a member of the immunoglobulin superfamily, is a novel marker to discriminate precursor exhausted T cells from terminally exhausted and bystander tumor …
百度学术
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CD83——免疫系统的重要调节分子 - 百度学术
本文介绍了CD83的结构、功能和在免疫应答中的作用，特别是在中枢淋巴细胞成熟中的调节作用。CD83是一种跨膜分子，是成熟树突状细胞的标志分子，也是T和B淋巴细胞的成熟因子。
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