2018年12月8日 · Adoptively transferring CD83 + CCR7 + NK cells aggravates EAU symptoms and increases the number of CD4 + IFN‐γ + T cells and dendritic cells (DCs) within the eye. These CD83 + CCR7 + NK cells then promote the maturation of DCs and IFN‐γ expression

2017年10月16日 · We found that the number of CD83 + CD3 − NK1.1 + cells was increased in the inflamed eyes and spleens of the EAU mouse model. At the recovery stage of EAU, serum concentrations of soluble CD83...

2019年6月6日 · Intracellular preformed CD83 protein is detected in a wide range of immune cells, including immature DC, monocytes, macrophages, natural-killer (NK) cells and lymphocytes (35). CD83 is rapidly transported to the surface from golgi and recycling endosome pools in DC, macrophages, monocytes and B-cells upon TLR or TNF engagement (37, 47).

2016年12月15日 · Surface CD83 expression is upregulated upon human DC activation (1) and is commonly used to identify DC maturation/activation. In addition, it is induced on activated human B cells (12, 13), monocytes (14), macrophages (14), neutrophils (15), and a …

Results of western blot experiments showed that the expressions of CD11b and CD83 within inflamed NK cells were lower following sCD83 treatment versus inflamed NK cells without sCD83...

Abstract. In addition to their cytotoxic activities, natural killer (NK) cells can have immunoregulatory functions. We describe a distinct “helper” differentiation pathway of human CD56 + CD3 − NK cells into CD56 + /CD83 + /CCR7 + /CD25 + cells that display high migratory responsiveness to lymph node (LN)–associated chemokines, high ability to produce interferon-γ upon exposure to ...

The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form ...

2005年10月3日 · We describe a distinct "helper" differentiation pathway of human CD56+CD3- NK cells into CD56+/CD83+/CCR7+/CD25+ cells that display high migratory responsiveness to lymph node (LN)-associated chemokines, high ability to produce interferon-gamma upon exposure to dendritic cell (DC)- or T helper (Th) cell-related signals, and pronounced abilities ...

2023年8月1日 · Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of...

In the present study, we examined whether human DC could affect NK activity. Both monocyte-derived and CD83 (+) blood DC were tested. The addition of DC to cultures of CD56 (+) cells resulted in the significant dose-dependent enhancement of the killing activity against various NK-sensitive targets.