2024年12月24日 · CDA (Cytidine Deaminase) is a Protein Coding gene. Diseases associated with CDA include Xeroderma Pigmentosum Group D and Acute Leukemia. Among its related pathways are Nucleotide salvage and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hydrolase activity.

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. [5][6][7] This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively.

2024年11月27日 · This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively.

2020年2月5日 · The recycling activity of cytidine deaminase (CDA) within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies, such as gemcitabine.

2025年2月8日 · This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool.

This gene encodes an Enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively.

Enables cytidine deaminase activity and identical protein binding activity. Involved in UMP salvage. Is active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog (s) of this gene implicated in lung non-small cell carcinoma.

基因简述 This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool.

2009年9月1日 · CDA catalyzes hydrolytic deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. This protein also inactivate chemotherapeutic nucleoside analogs 2,2-difluorodeoxycytidine (gemcitabine) and cytosine arabinoside (cytarabine, Ara-C).

2011年6月3日 · Cytidine Deaminase (CDA or CDD) Cytidine deaminase is a key enzyme involved in the pyrimidine salvage pathway and maintains the cellular pyrimidine supply. It is encoded by the human CDA gene. In the 1960s, cytosine nucleoside analogs, such as cytarabine, were reported to contain antitumor effects.