您可点击此处下载E Cadherin (CDH1)靶点介绍及实验小贴士pdf文件。 图一：E Cadherin靶点蛋白结构。 图片来源：SWISS-MODEL。 WB实验贴士. 钙黏蛋白是钙依赖性的细胞黏附蛋白。 在连接细胞时，它们优先以同种方式与自身相互作用。 因此，钙粘蛋白可能有助于异种细胞类型的分类。 E-Cadherin是一种单通道I型跨膜糖蛋白，定位于上皮细胞的黏附连接 (AJ)和基底外侧膜，由一个较大的胞外结构域、一个跨膜段和一个保守的胞质结构域组成。

Monoclonal Antibody for studying E-Cadherin. Validated for F, IF, IF, IHC, IHC, WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, E-Cadherin (24E10) Rabbit Monoclonal Antibody (CST #3195) is ready to ship.

Yeruva等人以CDH2（N-Cadherin）重组蛋白（购自义翘神州，货号： 11039-H03H）进行免疫染色解离、WB免疫印迹等分析，结果发现 致心律失常性心肌病 （AC）患者自身抗体对CDH2和DSG2具有催化活性，减少粘附分子间的相互作用。

CDH1，即钙粘蛋白1，别名E-cadherin、CD324、uvomorulin、ECAD和CDHE。 它是一种钙依赖性的细胞粘附分子，由人类基因组编码，在上皮细胞中高度表达。 CDH1的作用机制主要通过其跨膜结构域和细胞外钙粘蛋白重复序列，介导细胞间的同型粘附。

2019年2月25日 · E-cadherin Antibody (67A4) is a mouse monoclonal IgG1 kappa light chain antibody that detects human E-cadherin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM).

CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in …

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in …