VE-cadherin (CDH5)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白特性，蛋白表达，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27956-1-AP (CDH5 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CDH5，即血管内皮钙粘蛋白，别名VE-cadherin/Cadherin-5。 它是一种由CDH5基因编码的II型经典钙粘蛋白家族成员，主要在血管内皮细胞中表达。 CDH5的作用机制涉及介导内皮细胞间的同质性粘附，通过其细胞外结构域与相邻细胞的CDH5分子相互作用，形成稳定的粘附连接。

Yeruva等人以CDH2（N-Cadherin）重组蛋白（购自义翘神州，货号： 11039-H03H）进行免疫染色解离、WB免疫印迹等分析，结果发现 致心律失常性心肌病 （AC）患者自身抗体对CDH2和DSG2具有催化活性，减少粘附分子间的相互作用。

VE-钙粘蛋白也被称为钙粘蛋白5 (Cdh5)，是血管内皮的另一个有效标志。 Cdh5蛋白在内皮细胞连接处被发现，在那里它在内皮屏障功能和血管生成中起关键作用。

OriGene Anti-CDH5 Monoclonal (OTI1E1), TrueMAB™, Catalog # TA804747. Tested in Western Blot (WB) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (1 mg/mL).

Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance.

CDH5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially …

Flow cytometric analysis of Jurkat cells using CDH5 mouse mAb (green) and negative control (purple). This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer.

Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B .