2024年12月24日 · CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Prostate Cancer, Hereditary, 1 and Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat.

目前已知cdk12有三种主要功能：（1）cdk12磷酸化rna聚合酶polⅡ，促进转录的延伸；（2）cdk12与rna加工因子相互作用，调控剪接；（3）介导伴转录的rna聚合酶Ⅱ磷酸化和mrna 3’端加工，调节内含子的多聚腺苷化。

2021年1月27日 · cdk12是一种未来可期的癌症治疗靶标，在癌症发展中具有特定的背景作用，因此提供了一种低毒性的治疗方法。但是， 目前对cdk12生物学功能的理解被cdk12同源的cdk13所阻碍 。cdk13在激酶结构域中与cdk12具有92%的同源性，这导致实现cdk12和cdk13之间的选择性几乎 …

2020年5月25日 · Here, we discuss the diverse roles of CDK12 in gene expression regulation and human cancer, focusing on newly identified CDK12 kinase functions in cellular processes and highlighting CDK12 as...

CDK12在不同恶性肿瘤中扮演的角色不同， 在前列腺癌（prostatic cancer, PCA）中，CDK12 发挥着抑癌基因的功能。2021年的一项研究表明， 前列腺癌和卵巢癌是CDK12基因发生变异频率最高

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. [5] [6] [7] This enzyme is a member of cyclin-dependent kinase protein family.

Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation.

2024年3月19日 · Cell cycle-dependent protein kinase 12 (CDK12) plays a key role in a variety of carcinogenesis processes and represents a promising therapeutic target...

CDK12 has been demonstrated to specifically upregulate the expression of genes involved in response to DNA damage, stress and heat shock. More recent studies have implicated CDK12 in regulating mRNA splicing, 3' end processing, pre-replication complex assembly and genomic stability during embryonic development.

4 天之前 · cdk12是一种转录相关的细胞周期蛋白依赖性激酶，在dna复制、转录、损伤修复等过程中发挥重要作用，并与多种癌症相关。cdk12与cdk13共享较高序列相似性，导致特异性抑制剂的开发面临挑战。目前，尚无高选择性cdk12抑制剂进入临床。