Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. [5][6] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) …

2024年12月24日 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And …

2019年1月14日 · This has led to intense efforts to understand how CDK8/19 regulate diverse biological outputs and develop Mediator kinase inhibitors that can be exploited therapeutically. …

2010年1月24日 · Cyclin-dependent kinase 8 (CDK8), the kinase found in some variants of Mediator, has been characterized mostly as a transcriptional repressor. Recently, CDK8 was …

We focus on sequence-specific, DNA-binding transcription factors and other Mediator kinase substrates, and how CDK8 or CDK19 may enable metabolic and transcriptional …

2023年6月27日 · Here, a transcriptome-based screen of biologically active compounds uncovered that CDK8 inhibition was essential to enable chemically induced reprogramming from …

CDK8 belongs to a group of cyclin-dependent kinases involved in transcriptional regulation from yeast to mammals. CDK8 associates with the Mediator complex, but functions outside of …

To identify genes that both modulate β-catenin activity and are essential for colon cancer cell proliferation, we conducted two loss-of-function screens in human colon cancer cells and …

2018年6月28日 · Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating transcription either through its association with the Mediator complex or by phosphorylating transcription …

5 天之前 · On the other hand, CDK8 over-expression lines (CDK8-YFP #6 and CDK8-YFP #11) had higher green cotyledon percentages (Supplementary Fig. 1a, b) and longer primary roots …