Our findings suggest that the regulation of c-Myc in breast cancer cells is dependent on the molecular subtype, and that β-catenin-mediated regulation of c-Myc and p21 may control the balance of cell death and proliferation in breast cancer. Keywords: CDKN1A; Wnt; basal-like breast cancer; c-Myc; β-catenin. © 2015 Wiley Periodicals, Inc.

β-catenin regulates c-Myc and CDKN1A gene expression. To understand how β-catenin regulates c-Myc expression in breast cancer, we examined c-Myc mRNA and protein expression after knocking down β-catenin using siRNA transfection. c-Myc expression was decreased in …

In the present analysis, we have addressed the role of MYC and CDKN1A in the Wnt/β-catenin response that is required for developmentally scheduled hyaloid vessel regression. This has shown that the Wnt/β-catenin pathway co-receptors LRP5 and LRP6 both have activity in VECs that promotes hyaloid regression.

2023年4月24日 · Inhibition of c-MYC with the dominant-negative Omomyc protein relieves the DNA damage in CIII-deficient hepatocytes in vivo. Our results connect primary OXPHOS deficiency to genomic instability...

2021年1月11日 · Our RT–qPCR results showed that MYC repressed the mRNA level of CDKN1A and CDKN2B (Fig EV2H), indicating a transcriptional regulation by MYC. These data suggest that, in addition to transcriptional regulation of CDKN1A, MYC might also regulate the mRNA m 6 A modification of CDKN1A, and MYC might regulate CDKN2B only by transcription.

2018年6月14日 · We investigated whether the hyaloid Wnt response was linked to the oncogene Myc, and the cyclin-dependent kinase inhibitor CDKN1A (P21), both established regulators of cell cycle progression and cell death. Our analysis showed that the Wnt pathway co-receptors LRP5 and LRP6 have overlapping activities that mediate the Wnt/β-catenin signaling ...

c-MYC stimulates cell proliferation through the suppression of cyclin-dependent kinase (CDK) inhibitors including P15 (CDKN2B) and P21 (CDKN1A). It also activates E-box-mediated transcription of various target genes including telomerase reverse transcriptase (TERT) that is involved in cellular immor …

2015年2月11日 · β-catenin regulates c-Myc and CDKN1A expression in breast cancer cells. We previously reported that the Wnt pathway is preferentially activated in basal-like breast cancer.

2009年4月1日 · Here we present the expression chronologies of the target genes Ccnd1 (encoding for cyclin D1), Myc (c-Myc), Cdkn1a (p21 CIP1/WAF1), Tfrc (Transferrin receptor 1), Plf1 (Proliferin-1) and Ramp3 (Receptor activity-modifying protein …

2015年2月8日 · In addition, CDKN1A mRNA and p21 protein expression were significantly increased in all breast cancer cell lines upon β-catenin silencing. Interestingly, inhibiting β-catenin expression alone did not induce apoptosis in breast cancer cell lines despite c-Myc regulation, but we observed a modest increase of cells in the G1 phase of the cell ...