CDKN2A - Wikipedia
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. [5] . It is ubiquitously expressed in many tissues and …
CDKN2A Gene - GeneCards | ARF Protein | ARF Antibody
2024年12月24日 · CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) is a Protein Coding gene. Diseases associated with CDKN2A include Melanoma, Cutaneous Malignant 2 and Melanoma …
细胞周期蛋白依赖性激酶抑制因子 2A（CDKN2A）基因 | MCE
该 ARF 产品作为肿瘤抑制蛋白 p53 的稳定剂发挥作用，因为它可以与 E3 泛素蛋白连接酶 MDM2 相互作用并隔离， MDM2 是一种负责 p53 降解的蛋白质。 尽管存在结构和功能差异， CDK …
CDKN2A/2B拷贝数缺失肿瘤患者的特点、对免疫治疗的影响及靶 …
CDKN2A位于9号染色体，编码一个细胞周期素依赖性激酶抑制剂2a，是抑癌基因。 该基因至少有三种不同的剪接变异体被报道，其中两种被认为是CDK4激酶抑制剂。 另外一个变异体有ARF …
The CDKN2A (p16) Gene and Human Cancer - Molecular Medicine
1997年1月1日 · CDKN2A encodes a 156 amino acid, 16kD cell-cycle inhibitor protein, which normally blocks abnormal cell growth and proliferation by binding to complexes of cyclin …
CDKN2A基因 - 百度百科
CDKN2A基因也称多重肿瘤抑制基因（multiple tumor suppressor l，MTS1），由于其编码的蛋白质产物相对分子质量为16×10°，因此又称为P16基因。 Serrano等在1993年利用酵母双杂交蛋 …
CDKN2A gene - MedlinePlus
The CDKN2A gene provides instructions for making several proteins. The most well-studied are the p16 (INK4A) and the p14 (ARF) proteins. Both function as tumor suppressors, which …
CDKN2A germline alterations and the relevance of genotype …
2021年3月25日 · CDKN2A (cyclin dependent kinase inhibitor 2A, OMIM 600160) is a tumor suppressor gene that encodes for two proteins, namely p16 INK4A and p14 ARF, critical for …
Gene: CDKN2A (ENSG00000147889) - Summary - Homo_sapiens …
Chromosome 9: 21,967,751-21,995,300 reverse strand. GRCh37:CM000671.1. This gene has 17 transcripts (splice variants), 3 paralogues and is associated with 155 phenotypes. Show …
About Mutations in the CDKN2A Gene - Memorial Sloan Kettering Cancer Center
2023年7月17日 · While a CDKN2A mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives …