Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (C luster of D ifferentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.

The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed ...

2024年12月24日 · CEACAM1 (CEA Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CEACAM1 include Adenomatoid Tumor and Colorectal Cancer. Among its related pathways are Innate Immune System and MITF-M-dependent gene expression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

2023年12月25日 · CEACAM1、CEACAM5和CEACAM6被认为是 黑色素瘤 、肺癌、结直肠癌和胰腺癌的生物标志物和有前景的治疗靶点。 CEACAM5也称CEA，是一种广谱肿瘤标志物，在多种实体肿瘤表面过表达，用于辅助癌症检测。

癌胚抗原相关细胞黏附分子1 (carcino-embryonic antigen related cellular adhesion molecule1,CEACAM1),也被称作CD66a,胆汁糖蛋白 (biliar glyeoprotein,BGP)或者细胞-细胞黏附分子 (C-CAM),是一种细胞表面跨膜糖蛋白,也是癌胚抗原家族的一个成员,属于免疫球蛋白超家族黏附分子.CEACAM1广泛地 ...

2006年6月1日 · In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell...

该基因编码属于免疫球蛋白超家族的癌胚抗原 (CEA) 基因家族的成员。 CEA 家族的两个亚群，CEA 细胞粘附分子和妊娠特异性糖蛋白，位于 19 号染色体长臂上一个 1.2 Mb 的簇内。 CEA 细胞粘附分子亚群的 11 个假基因也在该簇中被发现。 编码的蛋白质最初在肝脏胆管中被描述为胆汁糖蛋白。 随后，发现它是一种在白细胞、上皮细胞和内皮细胞上检测到的细胞间粘附分子。 编码的蛋白质通过与该亚组其他蛋白质的嗜同性和异嗜性结合介导细胞粘附。 多种细胞活动归因 …

2018年7月2日 · CEACAM1 is essential for activation of CD8 + T cells, and the absence of CEACAM1 on virus-specific CD8 + T cells limits the antiviral CD8 + T cell response. Treatment with anti-CEACAM1 antibody...

Due to its multi-faceted role as a recently appreciated immune checkpoint inhibitor and tumor marker, CEACAM1 is an attractive target for cancer immunotherapy. Herein, we highlight CEACAM1's function in various immune compartments and cancer types, including in the context of metastatic disease.

CEACAM1 (formerly designated Bgp or CD66a) has the widest tissue distribution of all characterized family members. This receptor is not only found on epithelial cells, but also on various leukocytes and its expression can be induced on other cells, such as …