癌胚抗原相关细胞黏附分子6（Carcinoembryonic antigen-related cell adhesion molecule 6，CEACAM6），又称CD66c、NCA-90，属于免疫球蛋白细胞粘附分子CEA家族成员之一。 CEACAM6通过糖基磷脂酰肌醇（glycosyl phosphatidylinositol，GPI）连接在细胞膜上，定位于19号染色体q13.2，它编码的蛋白含344个氨基酸残基。 一般而言，CEACAMs都包含一个N端的免疫球蛋白可变区域（IgV）、一个跨膜区和一个细胞质区域。 CEACAMs通过同种亲和性相互 …

2024年12月24日 · CEACAM6 (CEA Cell Adhesion Molecule 6) is a Protein Coding gene. Diseases associated with CEACAM6 include Crohn's Disease and Gastrointestinal Carcinoma. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM1.

2024年5月25日 · Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily protein primarily expressed on epithelial surfaces and myeloid cells. It plays a significant role in cancer progression by inhibiting apoptosis, promoting drug resistance, and facilitating cancer cell invasion and metastasis.

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c (Cluster of Differentiation 66c), is a member of the carcinoembryonic antigen (CEA) gene family..

2019年12月4日 · We investigated biomarker CEACAM6, a highly abundant cell surface adhesion receptor that modulates the extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDA).

CEACAM6 acts as a receptor for adherent-invasive E. coli adhesion and is abnormally expressed by ileal epithelial cells in Crohn disease. CEA and CEACAM6 was shown to lead to an increase in the binding of the integrin alpha5beta1 receptor to its ligand fibronectin, without changing its cell surface levels, resulting in increased adhesion of CEA ...

2024年3月11日 · Our preclinical evidence demonstrates potential efficacy by delivering BET protein degrader to PDAC and its microenvironment via CEACAM6-targeted ADC. Pancreatic ductal adenocarcinoma (PDAC), a...

2023年12月25日 · 在整个癌胚抗原基因家族中，ceacam6是许多侵袭性肿瘤的最具特征性的生物学标志。 因此，CEACAM6有望作为药物靶点为肿瘤转移治疗带来全新策略。

该基因编码的蛋白质属于癌胚抗原 (CEA) 家族，其成员是糖基磷脂酰肌醇 (GPI) 锚定细胞表面糖蛋白。 该家族的成员在细胞粘附中发挥作用，并在癌症的血清免疫测定中广泛用作肿瘤标志物。 该基因影响肿瘤细胞对腺病毒感染的敏感性。 由该基因编码的蛋白质作为粘附侵入性大肠杆菌粘附在克罗恩病患者回肠上皮细胞表面的受体。 该基因与 19 号染色体上 CEA 家族细胞粘附分子亚群的基因和假基因聚集在一起。 [RefSeq 提供，2014 年 4 月]

CEACAM6 (CD66c) is a multi-functional glycoprotein that mediates homotypic binding with other CEA family members and heterotypic binding with integrin receptors. CEACAM6 functions by organizing tissue architecture and regulation of signal transduction, while aberrant expression leads to the development of human malignancies [10, 11].