EMBO | 着丝粒新见解有助于设计癌症新药 - 知乎
2023年2月22日 · 研究小组表明，在有丝分裂过程中，CENP-C蛋白与CENP-A结合，并作为其他着丝粒蛋白的支架。 然而，在分裂间期，一种不同的蛋白（KNL2）与着丝粒结合。 “KNL2包含 …
CENP-C unwraps the human CENP-A nucleosome through the H2A C …
2019年10月4日 · We provide new molecular insights into the structure of human CENP-A nucleosomes, in isolation and in complex with the CENP-C central region (CENP-C CR), the …
CENP-C is a blueprint for constitutive centromere–associated …
CENP-C promotes kinetochore targeting of other constitutive centromere–associated network (CCAN) subunits by directly interacting with the four-subunit CCAN subcomplex CENP-HIKM …
Centromere/kinetochore is assembled through CENP-C …
2023年6月8日 · Hara et al. find that CENP-C, a centromeric protein, is oligomerized through the Cupin domain in its C-terminal region. The oligomerization of the Cupin domain is essential for …
CENP-C reshapes and stabilizes CENP-A nucleosomes at the …
2015年5月8日 · Using purified components, we find that CENP-C reshapes the octameric histone core of CENP-A nucleosomes, rigidifies both surface and internal nucleosome structure, and …
CENP‐C unwraps the human CENP‐A nucleosome through the H2A C…
2019年9月2日 · We provide new molecular insights into the structure of human CENP ‐A nucleosomes, in isolation and in complex with the CENP ‐C central region (CENP ‐ CCR), the …
CENP-C Is a Structural Platform for Kinetochore Assembly
2011年3月8日 · Centromeric protein C (CENP-C) is a core component of this centromeric chromatin [3, 4] that, when depleted, prevents the proper formation of both centromeres and …
LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions …
2022年11月3日 · These findings uncover a non-centromere-derived lncRNA that recruits CENP-C to centromeres and shed critical lights on the function of centromeric DNA sequences as …
CENP-C is a blueprint for constitutive centromere-associated …
2015年7月6日 · CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. The role of CENP-C in …
CENP-C is a blueprint for constitutive centromere–associated network ...
CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. The role of CENP-C in CCAN organization, …