2024年12月24日 · CENPA (Centromere Protein A) is a Protein Coding gene. Diseases associated with CENPA include Crest Syndrome and Luminal Breast Carcinoma A. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Separation of Sister Chromatids.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. [5] CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome [6] in most eukaryotes including humans.

Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family.

Physics New Grad BBQ at CENPA - Sept 18th, 2024. Brynn Kristen MacCoy receives 2024 URA Honorary Doctoral Thesis Award. 2023 Annual Report. CENPA Group Photo 2023. 2022 Physics Award Winners . CENPA Group Photo 2021. First results from Muon g-2 experiment strengthen evidence of new physics. UW professors win 2021 Breakthrough Prize. CENPA Group ...

Focusing on the mammalian centromere- specific histone H3 variant, CENP-A, we highlight its coevolution with both centromeric DNA and its chaperone, HJURP. We then consider CENP-A de novo deposition and the importance of centromeric DNA recently uncovered with the added value from new ultra-long-read sequencing.

2024年10月9日 · cenpa在传统上被认为是着丝粒特异性组蛋白。 本研究发现CENPA通过与m 6 A-cenRNA的互作，在RNA表观遗传层面直接调控癌细胞中着丝粒完整性。 这提出了RNA表观转录参与核小体功能及表观遗传信息传递的新视角，为深入理解着丝粒形成、维持与调控提供了新的机制。

2021年3月26日 · CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin when overexpressed. Although CENP-A overexpression is a common...

2024年9月20日 · Here, we discovered elevated levels of m 6 A modification on centromeric RNA (cenRNA) in cancerous cells compared with non-cancerous cells. We then identified CENPA, an H3 variant, as an m 6 A reader of cenRNA. CENPA is localized at centromeres and is essential in preserving centromere integrity and function during mitosis.

2024年9月25日 · CENPA is localized at centromeres and is essential in preserving centromere integrity and function during mitosis. The m6A-modified cenRNA stabilizes centromeric localization of CENPA in cancer cells during the S phase of the cell cycle.

2023年10月16日 · The centromere proteins (CENPs), a critical mitosis-related protein complexes, are involved in the kinetochore assembly and chromosome segregation. In this study, we identified that CENPA was significantly up-regulated in HCC and highly expressed CENPA correlated with poor prognosis for HCC patients …