2004年4月15日 · In this study, we demonstrate that different Toll-like receptor (TLR) ligands induce distinct dendritic cell (DC) activation and immune responses in vivo. Thus, Escherichia coli LPS (TLR-4 stimulus), activates DCs to produce abundant IL-12 (p70), but little IL-10, and stimulates Th1 and Tc1 responses.

2017年10月30日 · T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory...

Pam-3-Cys, a TLR2 ligand (TLR2L), stimulates DCs via TLR2, leading to DC-mediated Th2 immune responses via the ERK-cFos pathway. Following ERK activation by Pam-3-Cys, the TcF cFOS is phosphorylated, which inhibits IL-12p70 expression, leading to the induction of Th2 responses in mice [129].

2024年12月26日 · 在静息状态下，c-Fos在细胞内的表达水平非常低，但一旦细胞受到外界刺激，如生长因子、细胞因子、神经递质、多肽激素或应激等，c-Fos的表达会迅速而短暂地诱导上调。 这种上调不依赖于蛋白质的合成，而是依赖于转录因子CREB（Cyclic adenosine monophosphate response element binding protein）和SRF（Serum response factor）的激活。 c-Fos蛋白在细胞内的作用主要是与c-Jun形成异二聚体，进而构成AP-1（Activator protein-1） …

2016年9月1日 · We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4...

In this study, we investigated the role of TLR2-induced Tpl2-ERK signaling in the regulation of pro- and anti-inflammatory markers (particularly IL-12/23p40 and IL-10) in macrophages and DCs. TLR2-mediated ERK activation was dependent on Tpl2 in both macrophages and DCs.

2006年12月11日 · Herein, we describe the phosphorylation of c-Fos tyrosine (tyr) residues and demonstrate its regulatory implications in events related to c-Fos/ER association and c-Fos-dependent phospholipid...

2008年6月20日 · 刘小龙研究组的博士研究生王晓明等研究人员发现介导D-J重排的D片段3′端RSS含有物种间高度保守的转录因子c-Fos/AP-1结合位点，在小鼠Tcrb重排过程中，c-Fos高水平表达并结合到该位点。 进一步的实验显示c-Fos招募RAG并促进RAG结合到D片段3′端RSS，增强D-J的重排并同时抑制V-D的重排，从而保证了D-J重排的优先性。 实验结果还揭示c-Fos/AP-1 的这种调控功能依赖于c-Fos与RAG的结合作用而不需c-Fos的转录调控作用。 更为重要的是，这 …

In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naïve CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, especially IL-4 and IL-13, is regulated in Th2 cells.

该原理图描绘了连续刷每根胡须，依次激活啮齿类动物体感觉皮层中特定“barrels”中的神经元群，通过c-FOS表达上调来识别 (用浅蓝色、橙色和绿色方块表示)。 因此，对c-FOS表达的检测和分析已为神经科学领域带来许多开创性进展。 为此，LifeCanvas现在进一步对其技术进行更新，以使整个组织中c-FOS蛋白的均匀标记成为可能。 这将支持神经科学家进行更广泛的研究，包括与疾病和年龄相关的对外部刺激的神经反应变化，学习和记忆的研究，检测脑肿瘤并通过整脑的3D …