Comparative gene identification-58 (CGI-58), also known as α/β-hydrolase domain-containing 5 (ABHD5), is a member of a large family of proteins containing an α/β-hydrolase-fold. CGI-58 is …

CGI-58 is now established to act as regulator of lipolysis in multiple tissues affecting both TG and PL metabolism. The function of CGI-58 as co-activator of ATGL provides an excellent rationale …

We tested the hypothesis that PNPLA3 interferes with ATGL activity by interacting with its cofactor, comparative gene identification-58 (CGI-58). Evidence supporting such an interaction …

脂肪甘油三酯脂肪酶 （ATGL） 在细胞内脂肪分解中起关键作用，可在与蛋白质比较基因鉴定 58 （CGI-58） 相互作用时被共激活。 CGI-58 刺激 ATGL 的潜在分子机制尚不完全清楚。 基于对 …

CGI-58(Comparative gene identification-58)分布在LDs表面, 属于α/β水解酶折叠家族, 是脂肪甘油三酯脂肪酶(Adipose triglyceride lipase, ATGL)和依赖酰基辅酶A溶血磷脂酸酰基转移 …

2015年10月10日 · Comparative gene identification-58 (CGI-58) stimulates the enzymatic activity of adipose triglyceride lipase (ATGL), which catalyzes the hydrolysis of TGs to diacylglycerols …

Our findings show that CGI-58 is a novel source of signaling lipids that links inflammation to TAG and glucose metabolism. Male C57BL/6N mice (Harlan) were maintained on standard rodent …

Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) …

CGI-58是带有α/β水解结构域的酶类,在体外它本身并不具有脂肪酶的活性,但它可以激活ATGL,使ATGL水解脂肪的活性大幅度提高。 ATGL和CGI-58的发现,对脂肪水解的传统理论提出了挑 …

2008年9月5日 · cgi-58 (c omparative g ene i dentification-58) is a member of α/β-hydrolase family of proteins. Mutations in CGI-58 are shown to be responsible for a rare genetic disorder known …