Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. [5][6][7] CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex. [8][9][10] The product of this gene belongs to the SNF2/RAD54 helicase family.

2024年12月24日 · CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Pallister-Hall Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.

2020年9月3日 · CHD4 neurodevelopmental disorder (CHD4-NDD) is associated with developmental delay, speech delay, and usually mild-to-moderate intellectual disability. Variability between individuals with CHD4-NDD is significant, and a few have normal intelligence. Other manifestations can include brain anomalies, heart defects, and skeletal abnormalities ...

CHD4是Nucleosome Remodeling和去乙酰化酶或NuRD (Mi-2) 复合物，与其他介导转录抑制的蛋白质组装。 我们回顾了证明 CHD4 对 B 谱系识别是必需的数据：早期 B 谱系进展、对白细胞介素 7 的反应增殖、对 DNA 损伤的反应和体内细胞存活。

该基因的产物属于 SNF2/RAD54 解旋酶家族。 它是核小体重塑和脱乙酰酶复合物的主要成分，在表观遗传转录抑制中起重要作用。 皮肌炎患者会产生针对这种蛋白质的抗体。 该基因的体细胞突变与浆液性子宫内膜肿瘤有关。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2014 年 7 月] The product of this gene belongs to the SNF2/RAD54 helicase family.

2019年8月7日 · The CHD4-related syndrome is a multisystemic neurodevelopmental disorder. Missense substitutions in different protein domains alter CHD4 function in a variant-specific manner, but result in a...

We show that CHD4 mediates rapid poly (ADP-ribose)-dependent recruitment of the NuRD complex to DNA-damage sites, and we identify CHD4 as a phosphorylation target for the apical DDR kinase ataxia-telangiectasia mutated. Functionally, we show that CHD4 promotes repair of DNA double-strand breaks and cell survival after DNA damage.

2022年12月6日 · CHD4 is an essential, widely conserved ATP-dependent translocase that is also a broad tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it alters chromatin...

CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A. Chd4 choreographs self-antigen expression for central immune tolerance. CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.

2020年7月9日 · Here, we report that conditional knockout of the chromatin remodeling enzyme Chd4 in granule neurons of the mouse cerebellum increases accessibility of gene regulatory sites genome-wide in vivo....