2024年12月24日 · CHD5 (Chromodomain Helicase DNA Binding Protein 5) is a Protein Coding gene. Diseases associated with CHD5 include Parenti-Mignot Neurodevelopmental Syndrome and Non-Specific Syndromic Intellectual Disability. Among its related pathways is Chromatin Regulation / Acetylation.

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene. [5] [6] [7] It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.

2014年5月13日 · Here we identify Chromodomain helicase DNA binding protein 5 (Chd5) as a master regulator of the histone-to-protamine chromatin remodelling process. Chd5 deficiency leads to defective sperm...

该基因编码一种神经元特异性蛋白质，可能在染色质重塑和基因转录中发挥作用。 该基因是一种潜在的抑癌基因，可能在神经母细胞瘤的发展中发挥作用。 [RefSeq 提供，2012 年 2 月] This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain.

Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as a tumor suppressor gene in a variety of malignancies. The aim of the current study was to clarify the clinical significance of CHD5 expression in gastric cancer.

2025年2月9日 · CHD5 is a potential tumour suppressor gene epigenetically silenced in hepatocellular carcinoma. The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping. repression of CHD5 gene expression in human leukemia is mediated in part by DNA methylation of its promoter.

Located in the critical 1p36 microdeletion region, the chromodomain helicase DNA-binding protein 5 (CHD5) gene encodes a subunit of the nucleosome remodeling and deacetylation (NuRD) complex required for neuronal development.

2012年6月1日 · Chromodomain helicase DNA binding protein 5 (CHD5) is a potent tumor suppressor that serves as a master regulator of a tumor-suppressive network. Examination of the role played by CHD5 in a wide range of human cancers is warranted. In this study, we focused on the epigenetic modification and tumor-suppressive role of CHD5 in lung cancer.

2022年5月6日 · CHD5 belongs to a group of SWI/SNF proteins called CHD proteins, which contain a SWI/SNF-like helicase/ATPase domain, as well as a DNA-binding domain and a chromodomain that directly modifies chromatin structure (Thompson et al., 2003).

2003年2月19日 · We have identified a novel gene encoding a protein with chromatin remodeling, helicase and DNA-binding motifs. This gene, called CHD5, is the fifth member of the CHD gene family identified in...