CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene …

2023年7月17日 · A CHEK2 gene mutation increases your risk for certain types of cancers. Your cancer risk may be different depending on the specific CHEK2 mutation you have. Most CHEK2 mutations increase your risk for breast cancer.

2019年8月27日 · CHEK2 is a tumor-suppressor gene that protects cells from becoming cancerous. People who inherit mutations in the gene are at increased for certain types of cancer and may benefit from more frequent screening. CHEK2 is the abbreviated name of the gene called checkpoint kinase 2.

2024年6月29日 · An inherited CHEK2 mutation may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

2021年10月4日 · CHEK2 serves the body as a tumor suppressor, but when it's mutated, it can be linked to numerous cancers. It is considered a more moderate-risk gene mutation. Today, most people have likely heard...

What You Should Know About CHEK2 Pathogenic/Likely Pathogenic Variants. Individuals with a pathogenic/likely pathogenic (P/LP) variant in the CHEK2 gene have an increased risk for cancers of the breast and prostate.

2020年8月24日 · These new guidelines recommend that people with CHEK2 mutations should consider family history and other factors to understand their risk for colorectal cancer and make decisions about their care.

2025年1月18日 · In this blog post, we will explore the CHEK2 gene and its critical functions, delve into the different types of CHEK2 mutations and their impact on cancer risk, discuss genetic testing and management strategies for mutation carriers, and look at the future of CHEK2-related research and therapies.

2024年12月24日 · CHEK2 (Checkpoint Kinase 2) is a Protein Coding gene. Diseases associated with CHEK2 include Tumor Predisposition Syndrome 4 and Prostate Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

2022年8月23日 · The CHEK2 gene gives your body instructions for making a protein called CHK2, which acts as a tumor suppressor. This means it keeps cells from growing and dividing too quickly. When DNA becomes...

2020年8月24日 · People with an inherited mutation in the CHEK2 gene have options for managing their cancer risk. Learn about the risk-management guidelines. FORCE is here to guide you.

2024年8月28日 · This monograph summarizes the interpretation of germline testing of the CHEK2 gene. It does not discuss indications for testing and is not intended to replace clinical judgment in the decision to test or in the clinical care of the individual who was tested.

• The job of the CHEK2 gene is to prevent cancer. It is called a tumor suppressor gene. When working correctly, tumor suppressor genes help to prevent cancer by controlling the growth and division of cells. • People born with a CHEK2 pathogenic variant have only one working copy of the CHEK2 gene, so their

A single founder allele of the CHEK2 gene has been associated with predisposition to breast and prostate cancer in North America and Europe. The CHEK2 protein participates in the DNA damage response in many cell types and is therefore a good ...

CHEK2. gene mutation raises the risk for breast, colorectal, and prostate cancers above the general population. The risks for other cancers can rise with . CHEK2. mutations, but ongoing research is providing more understanding. Most of the information known about . CHEK2. is based on a mutation called 1100delC. About 1% of people

What is my cancer risk if I have a CHEK2 mutation? A CHEK2 gene mutation increases your risk for certain types of cancers. Your cancer risk may be different depending on the specific CHEK2 mutation you have. Most CHEK2 mutations increase your risk for breast cancer.

2020年8月24日 · Learn about personalized treatment options for people with a CHEK2 mutation. People with an inherited CHEK2 mutation who have been diagnosed with cancer may have different treatment options than people without a mutation.

Checkpoint kinase 2 (CHEK2) is a gene that encodes a protein that functions as a regulator of the cell cycle as well as a tumor suppressor. The protein is activated in the presence of DNA damage in order to prevent entry into mitosis.

2022年5月25日 · Protein-truncating variants in the breast cancer susceptibility gene CHEK2 are associated with a moderately increased risk of breast cancer. By contrast, for missense variants of uncertain significance (VUS) in CHEK2 the associated breast cancer risk is often unclear.