2024年12月24日 · CIB1 (Calcium And Integrin Binding 1) is a Protein Coding gene. Diseases associated with CIB1 include Epidermodysplasia Verruciformis 3 and Inherited Epidermodysplasia Verruciformis. Among its related pathways are MAPK-Erk Pathway and Development Angiotensin activation of ERK.

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene and is located in Chromosome 15. [5][6][7] The protein encoded by this gene is a member of the calcium-binding protein family.

Calcium- and integrin-binding protein 1 (CIB1) is a small, ubiquitously expressed protein that was first identified as an intracellular binding partner of a platelet-specific α-integrin cytoplasmic tail. Although early studies revealed a role for CIB1 in regulating platelet integrin activity, recent …

Calcium- and integrin-binding protein 1 (CIB1) is a small, ubiquitously expressed protein that was first identified as an intracellular binding partner of a platelet-specific α-integrin cytoplasmic tail.

钙整合素结合蛋白1(CIB1)是一个含有EF-hand结构域的钙结合蛋白,可通过与不同信号分子的结合在多种生物学过程中发挥作用,参与调节细胞存活、增殖、黏附、迁移、血管新生等多种肿瘤特征性生物学过程。

2023年4月28日 · Overall, our findings identify CIB1 as a metabolic pathway-mediated factor for the restriction of immune cell infiltration in the stromal compartment of PDAC and highlight the potential value of CIB1 as a prognostic biomarker involved in metabolic reprogramming and immune modulation.

该基因编码包含 EF-hand 结构域的钙结合超家族的成员。 编码的蛋白质与许多其他蛋白质相互作用，包括血小板整合素 alpha-IIb-beta-3、DNA 依赖性蛋白激酶、早老素-2、粘着斑激酶、p21 激活激酶和蛋白激酶 D。 编码的蛋白质可能参与其中影响细胞存活和增殖，并与包括癌症和阿尔茨海默氏病在内的多种疾病状态相关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 4 月] This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily.

2021年2月27日 · Here, we show that in Arabidopsis thaliana, the bHLH transcription factor CRYPTOCHROME-INTERACTING BASIC HELIX-LOOP-HELIX 1 (CIB1) positively regulates cell elongation under the control of PIF4, PAR1, and HFR1.

2010年7月18日 · In this study, we identified CIB1 (also called calmyrin) as a previously unrecognized regulator of calcineurin-NFAT signaling and cardiac hypertrophy. CIB1 is widely expressed in various human...

2020年10月20日 · We show that CHIP can degrade CIB1 via promoting polyubiquitination of CIB1 and its subsequent proteasomal degradation. Besides, lysine residue 10 and 65 of CIB1 is the ubiquitinated site of...