2024年8月1日 · Cold-inducible RNA-binding protein (CIRP) is a versatile RNA-binding protein, pivotal in modulating cellular responses to diverse stress stimuli including cold shock, ultraviolet radiation, hypoxia, and infections, with a principal emphasis on cold stress. The temperature range of 32–34 °C is most suitable for CIRP expression.

2024年2月1日 · CIRBP is a conserved, stress-responsive RNA-binding protein. CIRBP acts as a regulator of key pathways such as cell cycle and inflammation. CIRBP regulations range from transcription to protein modification and localization. Alternative splicing mechanisms modulate CIRBP expression and function.

Cold-inducible RNA-binding protein (CIRP) is an RNA chaperone protein localized in nucleus and widely expressed in most tissue and organs. In recent years, numerous studies have confirmed that CIRP could be released from injured tissue and cells, interacting with immune cells and being involved in triggering inflammatory response as a damage ...

2020年9月24日 · 冷诱导RNA结合蛋白（cold inducible RNA-binding protein, CIRP）是一种RNA结合蛋白，属于冷休克蛋白家族，广泛表达于各种组织细胞中, 且在冷应激、缺氧、紫外线照射等过程中过量表达 。CIRP在细胞内外的定位不同，则其作用不同。

2022年5月4日 · Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are two evolutionarily conserved RNA-binding proteins that are transcriptionally upregulated in response to low temperature.

2013年10月6日 · Here we report increased levels of cold-inducible RNA-binding protein (CIRP) in the blood of individuals admitted to the surgical intensive care unit with hemorrhagic shock. In animal models...

Here we report increased levels of cold-inducible RNA-binding protein (CIRP) in the blood of individuals admitted to the surgical intensive care unit with hemorrhagic shock. In animal models of hemorrhage and sepsis, CIRP is upregulated in …

2017年6月12日 · After relocating into cytoplasm from nucleus, CIRP assists cells in adapting to novel environmental conditions via stabilizing specific mRNAs and facilitating their translation. It not only participates in anti-apoptosis processes under mild hypothermia condition, but also protects cells from ultraviolet radiation and hypoxia induced senescence ...

Cold-inducible RNA binding protein (CIRP) is a stress-induced protein that was initially described as a DNA damage-induced transcript (A18 hnRNP), as well as a cold-shock domain containing cold-stress response protein (CIRBP) that alters the translational efficiency of its target messenger RNAs (mRNAs).

Cold-inducible RNA-binding protein (CIRP) is a stress-response protein that is expressed in various types of cells and acts as an RNA chaperone, modifying the stability of its targeted mRNA. Intracellular CIRP could also be released into extracellular space …