2006年8月21日 · Methods: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. Results: The highest sensitivity was achieved for 14-3-3 and Tau in sporadic CJD (85% and 86%), and a combined determination of 14-3-3 and Tau, S100b, or NSE increased the sensitivity to over 93%.

2020年9月8日 · Creutzfeldt-Jakob disease (CJD) is a rare, fatal degenerative brain disorder caused by prion proteins. This condition belongs to a group of transmissible spongiform encephalopathies affecting people worldwide, with an incidence of 1 case per million per year.

Patients with suspected Creutzfeldt-Jakob disease (CJD) often have routine cerebrospinal fluid (CSF) analysis performed to exclude treatable inflammatory conditions; however, little information is available about the range of results obtained for …

The prion protein disorder Creutzfeldt-Jakob disease (CJD) is a human transmissible spongiform encephalopathy (TSE) that leads to rapid decay of brain tissue. Human prion diseases are either idiopathic such as sporadic or spontaneous CJD (sCJD), genetic or familial (fCJD), acquired such as iatrogenic CJD (iCJD) or variant CJD (vCJD).

May aid in the diagnosis of Creutzfeldt-Jakob disease (CJD). This test uses qualitative real-time quaking-induced conversion to identify the causative agent of CJD, and also includes indirect markers of neurodegenerative disease.

CSF RT-QuIC has a superior sensitivity and specificity for the diagnosis of sporadic CJD when compared to other CSF biomarkers including CSF 14-3-3. In our hands the sensitivity and specificity of CSF RT-QuIC is 94% and 100% respectively, compared to a sensitivity of 52% and a specificity of 96% for CSF 14-3-3.[1]

2022年4月21日 · Creutzfeldt-Jakob disease (CJD) is a severe, degenerative brain condition. It happens when faulty proteins, known as prions, damage your brain. This condition usually worsens very quickly, and most people don’t survive more than a year after diagnosis. Most cases of CJD happen for unknown reasons, but 10% to 15% of cases are inherited.

2022年4月6日 · The diagnosis of Creutzfeldt–Jakob disease has advanced from detection of characteristic EEG and MRI features to include the detection in CSF of 14-3-3 protein and, with the use of RT-QuIC ...

Pre- and posttest diagnostic probabilities for sporadic Creutzfeldt–Jakob disease (CJD), based on the data of Coulthart and colleagues, 15 for various illustrative concentrations of cerebrospinal fluid tau and S100B protein individually and in combination.

2024年12月15日 · CJD is a fatal prior disease with rapid progression, affecting 1–2 per million annually, with no cure. Types include sporadic, familial, and acquired CJD, sporadic is the most common comprising 85% of cases. Diagnosis involves MRI, EEG, and CSF markers like 14-3-3, but early detectionis difficult due to symptom overlap.