2022年3月15日 · We aim to examine BBB disruption, by assessing brain-derived neurotropic factor (BDNF), neuron-specific enolase (NSE) levels, and gut-blood barrier (GBB) disruption by trimethylamine N-oxide (TMAO), in chronic kidney disease (CKD) patients. Additionally, endothelial tight-junction protein expressions and modulation via TMAO were assessed.

2022年3月15日 · We aim to examine BBB disruption, by assessing brain-derived neurotropic factor (BDNF), neuron-specific enolase (NSE) levels, and gut-blood barrier (GBB) disruption by trimethylamine N-oxide...

2024年10月1日 · Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. This cognitive impairment is associated with an increased permeability of blood-brain barrier (BBB) in rodents with CKD, linked to activation of aryl hydrocarbon receptor (AhR) by indoxyl sulphate (IS).

2023年10月25日 · This study established a brain proteomic signature of CKD indicating BBB breakdown and insolubility of tau protein, which are pathologically linked to Alzheimer's disease. Urea-mediated activation of MMP2 was partly responsible for BBB breakdown in CKD.

2023年11月21日 · 日本东京医科齿科大学于2023年10月25日宣布，目前为止尚不清楚的慢性肾脏病（CKD）导致认知功能低下的分子机制的一部分已经阐明。 该研究由该大学研究生院医齿学综合研究科肾脏内科学领域的内田信一教授、万代新太郎助教、松木久住研究生、精神行动医学科学领域的高桥英彦教授、盐饱裕纪特纽阿特拉克准教授等研究小组进行。 研究成果被在线刊登在《Aging（Albany NY）》上。 在进化过程中，人的肾脏不仅具有循环血液的清洁（废物在尿中排 …

2024年12月1日 · The recently published article by Zimmermann et al. proposes an interesting and convincing explanation that linked the BBB permeability to neuronal dysfunction in the context of CKD, 8 focusing on potassium efflux in microglia, neurons, and interleukin (IL)-1b/IL-1R1 pathway by performing complementary in vitro and in vivo experiments ...

The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) ...

2023年8月1日 · We hypothesize that the reduction in proximal tubular transporters’ functionality in CKD leads to (1) the systemic retention of PBUTs, (2) a disruption of the BBB integrity and (3) an alteration of the activity of BBBec membrane transporters.

2023年12月20日 · The rupture of the blood-brain barrier (BBB) is a mechanism implicated in several neurodegenerative pathologies and systemic diseases with cerebral tropism. Recent experimental findings in CKD indicate that disruption of the BBB appears to be an important mechanism behind cognitive impairment in CKD.

We aim to examine BBB disruption, by assessing brain‐derived neurotropic factor (BDNF), neuron‐specific enolase (NSE) levels, and gut‐blood barrier (GBB) disruption by trimethylamine N‐oxide...